Observational studyCancer medicine2025
JMT103 versus Non-Denosumab or Denosumab Treatment in Chinese Patients with Unresectable or Surgically Challenging Giant Cell Tumor of Bone: A Propensity Score-Matched Comparison.
Observational study in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase Ib/II, Multicenter, Single-Arm, Open-Label Study to Evaluate the Efficacy and Safety of JMT103 in Surgically Unsalvageable or Refractory Giant Cell Tumor of Bone
A Real-world Study on Patients of Surgically Unsalvageable or Severe Post-surgery Morbidity Associated Giant Cell Tumor of Bone
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
backgroundGiant cell tumors of bone (GCTB) are RANK/RANK-ligand positive, progressive osteolytic tumors. There was no medical treatment for GCTB based on efficacy and safety data from Chinese patients. A single-arm, phase II study demonstrated the promising efficacy of JMT103 in unresectable or surgically challenging GCTB. Patient-level outcomes from the single-arm trial were compared with real-world data from denosumab or non-denosumab treated patients to estimate comparative efficacy in unresectable or surgically challenging GCTB.
methodsThe real-world data were retrospectively collected from three hospitals between January 2013 and December 2023. The eligibility criteria of the two cohorts were based on the JMT103 single-arm study. Propensity score matching was used to balance the baseline characteristics of patients in the JMT103 and the real-world cohorts. The primary endpoint was histopathological or 12 week radiological objective tumor response rate (OTR). Secondary endpoints included tumor response rate throughout the study, objective response rate, disease control rate, and safety profiles.
results166 and 135 patients were finally included in the non-denosumab and denosumab cohorts, respectively. After 1:1 nearest neighbor matching, the OTR of the JMT103 cohort was significantly higher than that of the non-denosumab cohort (94.2% vs. 4.8%), and was comparable with that of the denosumab cohort (92.0% vs. 67.0%). The same results were observed in tumor response rate throughout the study (JMT103 vs. non-denosumab: 94.2% vs. 4.8%, JMT103 vs. denosumab: 94.3% vs. 86.4%), objective response rate (83.5% vs. 11.1%, 87.4% vs. 80.0%), and disease control rate (100% vs. 70.4%, 100.0% vs. 98.8%).
conclusionJMT103 has manageable safety profiles with better effectiveness than non-denosumab and a trend toward greater effectiveness than denosumab in patients with unresectable or surgically challenging GCTB.
trial registrationNCT05402865, NCT04255576.
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Registered trials
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