Evidence map›Paper›PMID 41292137›Full record

ArticleClinical endocrinology2026

Resting Cerebrovascular Haemodynamics and Dynamic Assessment of Cerebrovascular Function in Polycystic Ovary Syndrome.

Cory T Richards, Thomas D Griffiths, Zoe H Adams, Melissa E Wright, Saajan Davies, Jack S Talbot, Lauren Broad-Thomas, Diego García Esteban, Jessica J Steventon, Patrice Brassard and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Cory T RichardsCardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK.ORCID https://orcid.org/0000-0003-3605-7044
Thomas D GriffithsCardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK.ORCID https://orcid.org/0000-0003-3104-4332
Zoe H AdamsCardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK.ORCID https://orcid.org/0000-0003-0187-0123
Melissa E WrightCardiff University Brain Research Imaging Centre (CUBRIC), School of Physics and Astronomy, Cardiff University, Cardiff, UK.ORCID https://orcid.org/0000-0002-2744-4504
Saajan DaviesCardiff University Brain Research Imaging Centre (CUBRIC), School of Physics and Astronomy, Cardiff University, Cardiff, UK.
Jack S TalbotCardiometabolic Health and Exercise Physiology Laboratory, Baker Heart and Diabetes Institute, Melbourne, Australia.ORCID https://orcid.org/0000-0003-0234-1426
Lauren Broad-ThomasCardiff and Vale University Health Board, Cardiff, UK.
Diego García EstebanCardiff and Vale University Health Board, Cardiff, UK.
Jessica J SteventonCardiff University Brain Research Imaging Centre (CUBRIC), School of Physics and Astronomy, Cardiff University, Cardiff, UK.
Patrice BrassardDepartment of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.ORCID https://orcid.org/0000-0002-6254-5044
Kevin MurphyCardiff University Brain Research Imaging Centre (CUBRIC), School of Physics and Astronomy, Cardiff University, Cardiff, UK.
Philip E JamesCardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK.
D Aled ReesNeuroscience and Mental Health Innovation Institute, School of Medicine, Cardiff University, Cardiff, UK.
Rachel N LordCardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK.ORCID https://orcid.org/0000-0002-5385-7548

Funding

The study was funded by The Waterloo Foundation (Grant #515818). T.D.G. is funded by the Knowledge and Exchange Skill Scholarship (Grant #CMK235), Z.H.A. is funded by the Academy of Medical Sciences Springboard Grant (SBF007\100 185, PI R.L.) and the Waterloo Foundation (Grant #1129-7651). M.E.W. and K.M. are funded by the Wellcome Trust (WT224267). Collaboration between P.B., C.T.R. and R.N.L. was supported by the 1st Wales-Québec Joint Call for Proposals.Wellcome Trust
6 · The paper itself

Abstract

objectiveDespite an increased cerebrovascular disease risk, the impact of Polycystic Ovary Syndrome (PCOS) on cerebrovascular haemodynamics and function is unknown. This study characterised cerebrovascular haemodynamics and function in women with PCOS versus healthy controls.

designCase-control study. PATIENTS: Fifteen women with PCOS (age: 31 ± 6 years; body mass index (BMI): 31.8 ± 5.7 kg/m MEASUREMENTS: Resting global cerebral blood (CBF) was assessed by 3T MRI. Middle- and posterior cerebral artery blood velocities (MCAv, PCAv) were measured by Doppler ultrasound and pulsatility index (MCA

resultsResting CBF (PCOS: 57.2 ± 7.5 ml/100 g/min; controls: 61.6 ± 11.6 ml/100 g/min, p = 0.25) and MCAv, PCAv, MCA

conclusionsCerebrovascular function is largely preserved in women with PCOS, although elevated arterial pulsatility and impaired vasodilatory response to carbon dioxide may indicate early endothelial dysfunction in the cerebral vasculature. Larger studies are needed to confirm this in view of our limited study power.

Indexed as

Cerebrovascular CirculationHemodynamicsPolycystic Ovary SyndromeAdultBlood Flow VelocityCase-Control StudiesFemaleHumansMagnetic Resonance ImagingMiddle Cerebral ArteryYoung AdultCerebral blood flowCerebrovascular CirculationDoppler UltrasonographyMagnetic Resonance ImagingNeurovascular CouplingPolycystic Ovary Syndrome

Identifiers

PMID41292137
PMCPMC12865755

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.