ReviewReproduction, fertility, and development2026
When less really is more: reducing embryo manipulation to lower metabolic stress and improving long term outcomes.
Review in Reproduction, fertility, and development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Fallopian tube: Biosensor and dynamic regulator of preimplantation development.PNAS nexus · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The use of assisted reproductive technologies (ARTs) to treat human infertility has increased exponentially in recent years. In addition to improved access to care for infertile patients, there is a significant increase in ART utilization in individuals without infertility, who electively chose to freeze their gametes and embryos for future use. Importantly, the number of procedures performed on eggs (egg freezing and thawing, increase in intracytoplasmic sperm injection (ICSI) utilization) and embryo (embryo biopsy for preimplantation genetic testing (PGT), freezing and thawing) has also increased over time. Here we review the laboratory animal evidence indicating how an increase in the number of procedures performed may be associated with increase in embryonic stress, altered in utero growth and possible neonatal and long-term consequences. These data suggest that minimizing the number of gamete and embryo procedures to the minimum required is a wise approach, while waiting for human data to provide further guidance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.