HDM and mannose as novel tolerogenic inducers for dendritic cells: mTOR/PPARγ-mediated attenuation of allergic asthma.

Fang Wang, Zhihui Min, Jiameng Gao, Yuhao Qian, Zhilong Jiang, Xiwen Gao, Zhihong Chen

Abstract read

In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Lp-PLA2-derived LysoPC drives dendritic cell immunogenic activation and Th17 inflammation in severe asthma.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fang Wang *Department of Respiratory and Critical Care Medicine of Zhongshan Hospital, Shanghai Institute of Respiratory Disease, Fudan University, Shanghai, China.

Zhihui Min *Biomedical Research Center of Zhongshan Hospital, Fudan University, Shanghai, China.

Jiameng GaoDepartment of Respiratory and Critical Care Medicine of Zhongshan Hospital, Shanghai Institute of Respiratory Disease, Fudan University, Shanghai, China.

Yuhao QianDepartment of Respiratory and Critical Care Medicine of Zhongshan Hospital, Shanghai Institute of Respiratory Disease, Fudan University, Shanghai, China.

Zhilong JiangDepartment of Respiratory and Critical Care Medicine of Zhongshan Hospital, Shanghai Institute of Respiratory Disease, Fudan University, Shanghai, China.

Xiwen GaoDepartment of Respiratory and Critical Care Medicine, Minhang Hospital, Fudan University, Shanghai, China. xiwengao@sina.com.

Zhihong ChenDepartment of Respiratory and Critical Care Medicine of Zhongshan Hospital, Shanghai Institute of Respiratory Disease, Fudan University, Shanghai, China. chenzhihong@xinhuamed.com.cn.

Funding

National Natural Science Foundation of China 82270026Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0506305

6 · The paper itself

Abstract

Dendritic cells (DCs) are pivotal in balancing immunity and tolerance in allergic asthma. This study reveals that both house dust mite (HDM) and mannose induce a potent tolerogenic phenotype in bone marrow derived DCs (BMDCs). These DCs display hallmark tolerogenic features, including a reduced proportion of DC-SIGN⁺ cells, downregulation of co-stimulatory molecules (MHC-II, CD80, and CD86) and key Th2-promoting factors (Jagged-1, OX40L), coupled with impaired phagocytosis and a reduced capacity to stimulate naïve CD4

Indexed as

AsthmaDendritic CellsImmune ToleranceMannosePPAR gammaPyroglyphidaeTOR Serine-Threonine KinasesAnimalsFemaleMiceMice, Inbred C57BLT-Lymphocytes, RegulatoryMannosemTOR protein, mousePPAR gammaTOR Serine-Threonine KinasesAsthmaDendritic cellsHouse dust miteImmunological tolerance

Identifiers

PMID41291936

DOI10.1186/s40001-025-03547-7

PMCPMC12751434

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.