Evidence map›Paper›PMID 41291905›Full record

ArticleAlzheimer's research & therapy2025

Increased levels of GFAP and purinergic P2X7 receptor in Alzheimer's disease brain are associated with Aβ, tau pathologies and synaptic loss.

Cinzia A Maschio, Oscar Moreno, Junlong Wang, Upasana Maheshwari, Annika Keller, Uwe Konietzko, Daniel Razansky, Agneta Nordberg, Axel Rominger, Christoph Hock and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. White matterAlzheimer's research & therapy · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cinzia A MaschioInstitute for Regenerative Medicine, University of Zurich, Wagistrasse 12, 9th floor, Zurich, 8952, Switzerland.
Oscar MorenoRadiochemistry and Nuclear Imaging Lab, CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), San Sebastián, 20014, Spain.
Junlong WangDepartment of Nuclear Medicine, Inselspital University of Bern, Bern, 3010, Switzerland.
Upasana MaheshwariDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, Zurich, 8091, Switzerland.
Annika KellerDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, Zurich, 8091, Switzerland.
Uwe KonietzkoInstitute for Regenerative Medicine, University of Zurich, Wagistrasse 12, 9th floor, Zurich, 8952, Switzerland.
Daniel RazanskyInstitute for Biomedical Engineering, University of Zurich & ETH Zurich, Zurich, 8093, Switzerland.
Agneta NordbergDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, 14183, Sweden.
Axel RomingerDepartment of Nuclear Medicine, Inselspital University of Bern, Bern, 3010, Switzerland.
Christoph HockInstitute for Regenerative Medicine, University of Zurich, Wagistrasse 12, 9th floor, Zurich, 8952, Switzerland.
Jordi LlopRadiochemistry and Nuclear Imaging Lab, CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), San Sebastián, 20014, Spain.
Roger M NitschInstitute for Regenerative Medicine, University of Zurich, Wagistrasse 12, 9th floor, Zurich, 8952, Switzerland.
Ruiqing NiInstitute for Regenerative Medicine, University of Zurich, Wagistrasse 12, 9th floor, Zurich, 8952, Switzerland. ruiqing.ni@uzh.ch.

Funding

MCIN/AEI/ 10.13039/501100011033 PID2023-148642OB-I00 and PID2020-117656RB-I00MCIN/AEI/ 10.13039/501100011033 PRE2019-089068Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 31ND30_213444
6 · The paper itself

Abstract

Astrogliosis plays an important role in Alzheimer’s disease(AD). We characterized glial fibrillary acidic protein(GFAP) and purinergic P2X7 receptor(P2X7R) alterations in AD and their associations with amyloid-β levels, tau pathology and synaptic density. Immunostaining(P2X7R, GFAP, amyloid-β, and phospho-tau) and autoradiography using [18F]JNJ-64413739 for P2X7R were performed in postmortem hippocampal and entorhinal cortex tissues from 42 AD patients and 35 nondemented-controls. Compared with nondemented-controls, AD hippocampi and the entorhinal cortex presented reactive astrocytes with increased GFAP and P2X7R levels. GFAP and P2X7R levels were positively correlated with amyloid-β, CERAD score, phospho-tau, and Braak stage and enriched around cored plaques. In conclusion, we found increased levels of GFAP and P2X7R in hippocampal and entorhinal cortex of AD patients compared with controls, associated with amyloid-β, tau, and Braak stage, highlighting the importance of astrogliosis in AD.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBrainGlial Fibrillary Acidic ProteinReceptors, Purinergic P2X7Synapsestau ProteinsAgedAged, 80 and overAstrocytesAutoradiographyEntorhinal CortexFemaleHippocampusHumansMaleAmyloid beta-PeptidesGFAP protein, humanGlial Fibrillary Acidic ProteinReceptors, Purinergic P2X7tau ProteinsAlzheimer’s diseaseAmyloid-βAstrogliosisGFAPP2X7RSynaptic densityTau

Identifiers

PMID41291905
PMCPMC12751640

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.