Evidence map›Paper›PMID 41291847›Full record

ArticleBioData mining2025

FARFOOD: a database of potential interactions between food compounds and drugs.

Ana María Nevado-Bulnes, Dixan Agustin Benitez, Guadalupe Cumplido-Laso, Jose María Carvajal-González, Sonia Mulero-Navarro, Angel-Carlos Román

Abstract read
In one paragraph

Article in BioData mining, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ana María Nevado-BulnesServicio Extremeño de Salud (SES), C/Charcón s/n, Almaraz, 10350, Spain.
Dixan Agustin BenitezDepartamento de Bioquímica y Biología Molecular y Genética, Universidad de Extremadura, Avda de Elvas s/n, Badajoz, 06071, Spain.
Guadalupe Cumplido-LasoDepartamento de Bioquímica y Biología Molecular y Genética, Universidad de Extremadura, Avda de Elvas s/n, Badajoz, 06071, Spain.
Jose María Carvajal-GonzálezDepartamento de Bioquímica y Biología Molecular y Genética, Universidad de Extremadura, Avda de Elvas s/n, Badajoz, 06071, Spain.
Sonia Mulero-NavarroDepartamento de Bioquímica y Biología Molecular y Genética, Universidad de Extremadura, Avda de Elvas s/n, Badajoz, 06071, Spain. smmulero@unex.es.
Angel-Carlos RománDepartamento de Bioquímica y Biología Molecular y Genética, Universidad de Extremadura, Avda de Elvas s/n, Badajoz, 06071, Spain. acroman@unex.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nutrition is a fundamental aspect in human life development, both from a socio-economic and medical perspective. In recent years, new personalized approaches have been added to the biochemical study of nutrients. These approaches consider both the effect of foods on the body and the role of genes in metabolizing or digesting different nutrients. Drug-food interactions have been known for decades, and databases like FooDrugs include curated interactions from multiple sources. In this paper we develop a method to predict potential interactions between foods and drugs based on the structural similarity between food compounds and medications. Our results have produced a database and an app to consult potential interactions between drugs and foods that we have called FARFOOD. Additionally, we validated two of these potential interactions with widely used drugs (lisinopril and bupropion) through structural docking between the ligand protein and the food compounds that are structurally similar to the drug. Moreover, patient surveys are used in the lisinopril and bupropion cases in addition to allopurinol to assess the possible effects of the potentially interacting foods on the symptoms of the conditions for which the medication is prescribed. In summary, this manuscript presents an interesting computational resource for predictive food-drug interaction analysis.

Indexed as

AllopurinolBupropionFood-drug interactionsIn silico modelingLisinopril

Identifiers

PMID41291847
PMCPMC12645732

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.