ArticleArchives of public health = Archives belges de sante publique2025
Environmental greenery and skin cancer risk: a prospective cohort study on incidence and mediating mechanisms.
Article in Archives of public health = Archives belges de sante publique, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Revealing key biomarkers and molecular mechanisms associated with di(2-ethylhexyl) phthalate in skin cancer.Frontiers in molecular biosciences · 2026Article
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Authors and funding
12 authors.
Funding
Abstract
backgroundSkin cancer, including malignant melanoma (MM) and non-melanoma skin cancer (NMSC), is a growing global public health problem. Green spaces are generally beneficial to public health, yet their impact on skin cancer risk remains contentious.
methodsUsing data from 318,738 participants in a large cohort, we examined the association between green space, domestic gardens, and natural environments within 300-m and 1,000-m buffer zones and skin cancer incidence. Hazard ratios (HRs) were estimated using Cox regression. Genetic susceptibility was assessed through polygenic risk scores, susceptible populations were identified through gene-environment interaction, potential biomarkers were discovered through metabolomics, and potential pathways were explored through mediator analyses.
resultsDomestic gardens are the main type of greenery associated with an increased risk of skin cancer. The highest quartile of exposure to gardens resulted in a 23% increased risk of developing MM (HR = 1.23, 95% CI: 1.08-1.41). People living within 300 m (HR = 1.10, 95% CI: 1.05-1.16) and 1,000 m (HR = 1.11, 95% CI: 1.06-1.17) of a garden had a higher risk of developing NMSC. Interaction analyses of domestic gardens with genetic characteristics showed that genetically susceptible, light-skinned, and sun-sensitive populations were at higher risk of cancer. Metabolomics identified metabolites (e.g., histidine) and NMSC markers (e.g., tyrosine) associated with MM. Unexpectedly, PM
conclusionsWe found that domestic gardens have a significant effect on skin cancer risk according to the type of greenery. Urban planning should target genetically and phenotypically susceptible populations with protective measures.
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