Evidence map›Paper›PMID 41291694›Full record

SynthesisMalaria journal2025

Genetic diversity, population structure, and drug resistance of Plasmodium falciparum in Kenya: a systematic review and meta-analysis.

Josphat Nyandieka Nyataya, Mathijs Mutsaers, Clement Asabo Masakhwe, Ann Cheptoo Laigong, Johanna Helena Kattenberg, Anna Rosanas-Urgell, John Njenga Waitumbi

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Malaria journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Josphat Nyandieka NyatayaBasic Science Laboratory, Kenya Medical Research Institute (KEMRI)/Walter Reed Army Institute of Research-Africa, Kisumu Field Station, Kisumu, Kenya.
Mathijs MutsaersBiomedical Sciences Department, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.
Clement Asabo MasakhweBasic Science Laboratory, Kenya Medical Research Institute (KEMRI)/Walter Reed Army Institute of Research-Africa, Kisumu Field Station, Kisumu, Kenya.
Ann Cheptoo LaigongBasic Science Laboratory, Kenya Medical Research Institute (KEMRI)/Walter Reed Army Institute of Research-Africa, Kisumu Field Station, Kisumu, Kenya.
Johanna Helena KattenbergBiomedical Sciences Department, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.
Anna Rosanas-UrgellBiomedical Sciences Department, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.
John Njenga WaitumbiBasic Science Laboratory, Kenya Medical Research Institute (KEMRI)/Walter Reed Army Institute of Research-Africa, Kisumu Field Station, Kisumu, Kenya. John.Waitumbi@usamru-k.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A systematic review and meta-analysis of studies carried out in Kenya to assess Plasmodium falciparum genetic diversity and drug resistance was conducted with the aim of tracking parasite dynamics over time and space. In Kenya, malaria has declined in certain regions making it an ideal setting to investigate the impact of control interventions on the parasite population. A systematic electronic search yielded a total of 737 articles from PUBMED (392), google scholar (105) science direct (16) and Web of Science (224). Of these, 58 articles published in Kenya between 2002 and 2023 were eligible and included 21 articles on P. falciparum genetic diversity and 37 articles on drug resistance. Two independent reviewers performed screening, quality and risk of bias assessment and data extraction. Non-parametric tests were used to assess temporal trends. Heterogeneity across studies was assessed using I

Indexed as

AntimalarialsDrug ResistanceGenetic VariationMalaria, FalciparumPlasmodium falciparumHumansKenyaAntimalarialsDrug resistanceGenetic diversityKenyaMultiplicity of infectionPlasmodium falciparumPopulation structure

Identifiers

PMID41291694
PMCPMC12751886

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.