Trial reportBMC oral health2025
Effectiveness of topical vacuum assisted drainage in mandibular third molar surgeries: a randomized controlled clinical study.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06758258 (Evaluating the Impact of Negative Pressure Wound Therapy on Inflammatory Symptom Severity Following Impacted Third Molar Extractions), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating the Impact of Negative Pressure Wound Therapy on Inflammatory Symptom Severity Following Impacted Third Molar Extractions
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to evaluate the clinical efficacy of intraoral vacuum-assisted drainage (VAD) in reducing postoperative inflammatory complications-pain, swelling, and trismus-following the surgical extraction of impacted mandibular third molars (M3M). MATERIALS AND
methodsA prospective, randomized, triple-blinded, sham-controlled clinical trial was conducted with 36 systemically healthy participants undergoing surgical removal of a single M3M. Participants were randomly assigned to either the VAD group (n = 18), receiving three sessions of intraoral negative pressure therapy via a custom-made splint, or the sham-control group (n = 18), in which the apparatus was applied without suction. Primary outcomes included pain intensity, facial swelling, and maximum mouth opening (MMO), measured preoperatively and on the 2nd and 7th postoperative days. Secondary outcomes were NSAID consumption and oral health-related quality of life (OHIP-14). Statistical analysis was conducted with a significance level of 0.05.
resultsThe VAD group showed significantly lower pain scores at all postoperative time points compared to controls (p < 0.05). Swelling was significantly reduced on postoperative day 2 (p = 0.019), and MMO was significantly greater on both postoperative days 2 and 7 (p < 0.001 and p = 0.001, respectively). Nonsteroidal anti-inflammatory drug consumption was significantly lower in the VAD group (8.1 ± 3.2 vs. 12.8 ± 4.6 tablets, p = 0.001), and OHIP-14 scores indicated improved quality of life on postoperative day 7 (p = 0.021).
conclusionsWithin the limitations of this preliminary trial, vacuum-assisted drainage showed potential in reducing early postoperative complications following M3M surgery. These findings support further investigation into its clinical application. CLINICAL RELEVANCE: This study introduces an innovative intraoral vacuum-assisted drainage technique that enhances patient recovery after mandibular third molar surgery. By reducing inflammatory complications and analgesic dependency, it offers a promising adjunct to standard postoperative care, particularly in patients where NSAID use is limited or adverse effects are a concern.
trial registrationClinicalTrials.gov Identifier NCT06758258. Date of Registration 26/11/2024 (retrospectively registered).
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