Trial reportBMC oral health2025
The effect of cryotreated sodium hypochlorite irrigation at different concentrations on postoperative pain in mandibular first molars with symptomatic irreversible pulpitis: a randomized controlled clinical trial.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06820996 (Effect of Cryotreated Sodium Hypochlorite Irrigation at Different Consentrations in Mandibular First Molars With Symptomatic Irreversible Pulpitis), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Effect of Cryotreated Sodium Hypochlorite Irrigation at Different Consentrations in Mandibular First Molars With Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial
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Authors and funding
2 authors.
Funding
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Abstract
backgroundThe purpose of this study was to evaluate the effects of cryotreated 2.5% and 5% sodium hypochlorite (NaOCl) on postoperative pain during endodontic treatment procedures in mandibular first molars with symptomatic irreversible pulpitis.
methodsOne hundred and thirty two patients with permanent mandibular first molars diagnosed with symptomatic irreversible pulpitis were included in the study. The teeth were randomly divided into four groups: the normal 2.5% NaOCl group (n = 33), the cryotreated 2.5% NaOCl group (n = 33), the normal 5% NaOCl group (n = 33) and the cryotreated 5% NaOCl group (n = 33). In the normal NaOCl groups, the root canals were irrigated with NaOCl solution at 25 °C at all stages of the root canal treatment. In the cryotreated NaOCl groups, the root canals were irrigated with NaOCl solution at 2 °C at all stages of the root canal treatment. The participants were asked to rate the intensity of their postoperative pain via a Visual Analog Scale (VAS) at 6 h, 12 h, 24 h, 48 h, and 72 h. The data were analyzed using the Shapiro-Wilk, Levene’s, Kruskal Wallis H and the Chi-square test.
resultsThe basic demographic data, preoperative pain values and analgesic intake of the four study groups were similar. Postoperative pain levels at 6 h were significantly lower in the cryotreated 2.5% NaOCl group than in all the other groups (p < .05). Postoperative pain levels at 12 h were statistically similar between the cryotreated 2.5% NaOCl group and the cryotreated 5% NaOCl group (p > .05) and significantly lower than those in the other two groups (p < .05).
conclusionsUsing cryotreated NaOCl irrigation at different concentrations during root canal treatment procedures in mandibular first molars with symptomatic irreversible pulpitis effectively reduced postoperative pain.
trial registrationThis study was registered at ClinicalTrials.gov (NCT06820996) on 11 February 2025.
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