Evidence map›Paper›PMID 41291584›Full record

SynthesisBMC pediatrics2025

Can vitamin D supplementation affect cardiometabolic factors in children and adolescence with overweight and obesity? A grade-assessed systematic review and meta-analysis of randomized controlled trials.

Amir Hossein Faghfouri, Mahsa Mahmoudinezhad, Pedram Pam, Sanaz Barazandeh, Fatemeh Faramarzi, Yousef Mohammadpour, Vali Musazadeh, Shahsanam Gheibi

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amir Hossein FaghfouriMaternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Mahsa MahmoudinezhadStudent Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
Pedram PamStudent Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
Sanaz BarazandehStudent Research Committee, School of Public Health, Iran , University of Medical Sciences, Tehran, Iran.
Fatemeh FaramarziMaternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Yousef MohammadpourPatient Safety Research Center, School of Medicine, Clinincal Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
Vali MusazadehStudent Research Committee, School of Public Health, Iran , University of Medical Sciences, Tehran, Iran. Mosazadeh.vali05@gmail.com.
Shahsanam GheibiMaternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran. gheibi1345sh@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D have been proposed as a supplement to improve cardiometabolic risk factors in obese/overweight children and adolescents. However, findings evidence remains inconsistent. This meta-analysis aimed to assess the effects of vitamin D supplementation on cardiometabolic risk factors in obese/overweight children and adolescents.

methodsA systematic review of PubMed, Embase, Scopus, Web of Science, Cochrane Library, and Google Scholar up to April 2025 was searched. This study aimed to evaluate the effect of vitamin D supplementation on cardiometabolic factors including anthropometric indices, glycemic state and lipid profile. Data were pooled using a random-effects model to calculate weighted mean differences (WMDs) and 95% confidence intervals (CIs).

resultsNine studies with 440 participants were included. The meta-analysis revealed that vitamin D supplementation no significantly improved BMI, BMI-Z, FBS, insulin, HOMA-IR, QUICKI, TG, TC, and LDL-C. However, it was accompanied with a significant reduction in HDL-C level. Subgroup-analysis showed that vitamin D

conclusionsThe current meta-analysis revealed vitamin D supplementation has no favorable effect on cardiometabolic risk factors. More high-quality and large-scale trials are needed to provide more robust evidence.

Indexed as

Cardiometabolic Risk FactorsDietary SupplementsOverweightPediatric ObesityVitamin DVitaminsAdolescentChildHumansRandomized Controlled Trials as TopicVitamin DVitaminsBiochemicalLipidMeta-analysisSupplementationVitamin D

Identifiers

PMID41291584
PMCPMC12645772

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.