Observational studyBMC geriatrics2025
Cumulative effect of intrinsic capacity domains on geriatric syndromes and functionality in older inpatients.
Observational study in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Association between extreme temperature events and intrinsic capacity trajectories among middle-aged and older adults: the China Health and Retirement Longitudinal Study (CHARLS).BMC public health · 2026Article
- Leveraging interpretable machine learning to identify sarcopenia in middle-aged and older adults with intrinsic capacity decline: an analysis of CHARLS data under AWGS 2025.BMC medical informatics and decision making · 2026Article
- Prevalence and associated factors of geriatric syndromes using an online self-administered screening tool based on the ICOPE framework in primary care.BMC geriatrics · 2026Article
- Perceptions on healthy aging: insights from focus group interviews of older adults in Sweden.Archives of public health = Archives belges de sante publique · 2026Article
- Number of natural teeth and intrinsic capacity among hospitalized older adults in China: a cross-sectional study on the role of social support.Frontiers in medicine · 2026Article
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Authors and funding
5 authors.
Funding
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Abstract
introductionIntrinsic capacity (IC), as defined by the World Health Organization, represents the composite of an individual's physical and mental capacities and provides a multidimensional framework for assessing older adults' functional reserve. It includes five domains: locomotion, vitality, cognition, psychological well-being, and sensory function. This study aimed to examine the associations between IC domains and common geriatric syndromes in hospitalized older adults.
methodsIn this retrospective observational study, 245 patients aged ≥ 60 years who underwent comprehensive geriatric assessment were included. IC was evaluated across five domains using standard tools: gait speed, self-reported sensory deficits, Standardized Mini-Mental State Examination (S-MMSE), Euro Quality of Life 5 Domain (EuroQOL-5D) and Mini Nutritional Assessment. The IC score ranges from 0 to 5, with higher scores indicating better intrinsic capacity, and a score ≤ 2 representing moderate-severe decline. Geriatric syndromes assessed were frailty, probable sarcopenia, falls, urinary incontinence, and functional impairments in Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL). Logistic regression models identified predictive IC domains, adjusting for age, sex, polypharmacy, and comorbidity.
resultsNearly 60% of participants had moderate to severe IC decline (score ≤ 2). Vitality and locomotor impairments were the most common. Cognitive and vitality impairments were strongly associated with both ADL and IADL disability (p < 0.001), while locomotor and vitality impairments predicted probable sarcopenia and frailty (p < 0.01). Cognitive impairment was linked to a nearly six-fold increased fall risk (OR = 5.86, 95% CI: 2.51-13.68, p < 0.001). The models showed good discrimination, with an area under the curve value of 0.723 for falls and 0.854 for ADL disability.
conclusionsIC impairments, particularly in cognition, vitality, and locomotion, are prevalent and predictive of major geriatric syndromes in hospitalized older adults. Routine IC assessment may help identify at-risk individuals and inform targeted interventions.
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