Evidence map›Paper›PMID 41291490›Full record

ReviewBMC neurology2025

A case of folinic acid, fluorouracil and oxaliplatin (FOLFOX) chemotherapy regimen associated neurotoxicity and review of literature.

Juhi Srivastava, Esha Kataria DO, Sanjeev Sivakumar, Naresh Mullaguri

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A Colon Cancer Organoid-on-a-Chip Model for In Vitro Therapy Assessment.International journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Juhi SrivastavaNeurology Resident physician, Prisma Health Greer Neurology Program, Greer, SC, USA.
Esha Kataria DONeurology Resident physician, Prisma Health Greer Neurology Program, Greer, SC, USA.
Sanjeev SivakumarNeurocritical care, Prisma Health Neurology, Greenville Memorial Hospital, 701 Grove Road, Greenville, SC, 29615, USA.
Naresh MullaguriNeurocritical care, Prisma Health Neurology, Greenville Memorial Hospital, 701 Grove Road, Greenville, SC, 29615, USA. naresh.mullaguri@prismahealth.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

FOLFOX (folinic acid, 5-fluorouracil, and oxaliplatin) chemotherapy regimen is a widely used chemotherapy agent for the management of gastrointestinal malignancies. FOLFOX has been linked to various toxicities including peripheral neurotoxicity. We report a case of central neurotoxicity demonstrated clinically and radiographically within 24 h of FOLFOX administration in a patient with metastatic gastric adenocarcinoma. We further review these clinical and radiographic characteristics to help guide treatment and management of these patients.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsNeurotoxicity SyndromesAdenocarcinomaFemaleFluorouracilHumansLeucovorinMaleMiddle AgedOrganoplatinum CompoundsOxaliplatinStomach NeoplasmsFluorouracilLeucovorinOrganoplatinum CompoundsOxaliplatin5-FluorouracilChemotherapyGastric adenocarcinomaNeurotoxicityUridine triphosphate

Identifiers

PMID41291490
PMCPMC12648844

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.