ReviewInternational journal of emergency medicine2025
Visualizing the prognostic value of neuron-specific enolase in acute ischemic stroke: a bibliometric analysis.
Review in International journal of emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIn recent years, neuron-specific enolase (NSE) has been explored as a suitable biomarker for cerebral damage, specifically following ischemic stroke. This bibliometric analysis sought to illuminate patterns in research published on NSE’s value as a biomarker for ischemic stroke by examining prominent authors, keywords, countries, and organizations in this field.
methodsWe conducted a bibliometric analysis using the Web of Science Core Collection. Publications were retrieved using the search string “ischemic stroke (Topic) AND enolase (Topic)” without language restriction, from database inception to June 2025. Extracted metadata were analyzed using VOSviewer (v1.6.20) to generate co-authorship, co-citation, and keyword maps. Analyses characterized key authors, institutions, and countries; mapped keyword co-occurrence; and described temporal trends. Bibliometric analysis was used to contextualize NSE’s prognostic value in ischemic stroke.
resultsA total of 465 documents were retrieved. China, the United States, and Germany were the most productive countries, with the U.S. having the highest citation impact. The University of Florida, Capital Medical University, and Central India Institute of Medical Sciences led institutional output. Ronald L. Hayes, Hatim F. Daginawala, and Robert S. B. Clark emerged as leading authors, with Clark having the highest citations. Frequently occurring keywords included “neuron-specific enolase,” “acute ischemic stroke,” and “cerebrospinal fluid.” Publication activity accelerated after 2016, with a notable rise from 2023 onward.
conclusionThis bibliometric mapping reveals global but fragmented research on NSE as a biomarker for ischemic stroke. While NSE shows promise, clinical studies remain inconsistent regarding its predictive value, highlighting the need for large-scale, multicenter investigations. Bibliometric analysis helps identify gaps and collaborations critical to advancing NSE’s translation into clinical practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.