Evidence map›Paper›PMID 41291361›Full record

ArticleAnnals of surgical oncology2026

The Role of HIPEC in Isolated Cytology-Positive Gastric Cancer: Nodal Metastasis Dominates Prognosis, HIPEC Remains Unproven.

Kunal Nandy, Amir Parray, Akshay Dhaiya, Amit Chopde, Vishnu Menon, Vikas Ostwal, Anant Ramaswamy, Prabhat Bhargav, Manish S Bhandare, Shailesh V Shrikhande and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kunal NandyDivision of GI and HPB Surgery, Department of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Parel, Mumbai, India.
Amir ParrayDivision of GI and HPB Surgery, Department of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Parel, Mumbai, India.
Akshay DhaiyaDivision of GI and HPB Surgery, Department of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Parel, Mumbai, India.
Amit ChopdeDivision of GI and HPB Surgery, Department of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Parel, Mumbai, India.
Vishnu MenonDivision of GI and HPB Surgery, Department of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Parel, Mumbai, India.
Vikas OstwalDepartment of Medical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Parel, Mumbai, India.
Anant RamaswamyDepartment of Medical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Parel, Mumbai, India.
Prabhat BhargavDepartment of Medical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Parel, Mumbai, India.
Manish S BhandareDivision of GI and HPB Surgery, Department of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Parel, Mumbai, India.
Shailesh V ShrikhandeDivision of GI and HPB Surgery, Department of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Parel, Mumbai, India.
Vikram A ChaudhariDivision of GI and HPB Surgery, Department of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Parel, Mumbai, India. drvikramchaudhari@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe therapeutic role of hyperthermic intraperitoneal chemotherapy (HIPEC) in isolated cytology-positive (Cy

methodsWe retrospectively analyzed 558 patients with gastric adenocarcinoma who received neoadjuvant chemotherapy followed by radical gastrectomy (2017-2023). Propensity score matching (1:5) balanced 47 Cy

resultsCy

conclusionCytology positivity independently predicted poor survival after curative gastrectomy, but nodal status was the dominant prognostic determinant. HIPEC was well tolerated but conferred no significant survival advantage, underscoring its investigational role pending prospective validation.

Indexed as

AdenocarcinomaAntineoplastic Combined Chemotherapy ProtocolsHyperthermic Intraperitoneal ChemotherapyPeritoneal NeoplasmsStomach NeoplasmsAdultAgedFemaleFollow-Up StudiesGastrectomyHumansLymphatic MetastasisMaleMiddle AgedNeoadjuvant TherapyPrognosisCytology-positiveGastric cancerHIPECNodal metastasisPeritoneal recurrencePrecision oncologyPropensity-matched

Identifiers

PMID41291361
PMCPMC12982269

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.