ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
Nutritional surveillance from surgery to post-radiotherapy in oral cavity cancer: a prospective longitudinal study.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis prospective longitudinal study evaluated nutritional changes in patients with oral cavity cancer undergoing multimodal treatment and examined the impact of nutritional status on clinically meaningful outcomes, including mortality and 30-day readmissions.
methodsOne hundred patients undergoing surgery followed by radiotherapy were assessed at five time points (V0-V4). Nutritional evaluations included body weight, body mass index (BMI), bioelectrical impedance analysis (BIA), handgrip strength (HGS), serum albumin, and dietary intake. Primary outcomes were mortality 30-day readmissions and mucositis severity. Secondary outcomes included length of hospital stay (LOHS), and radiotherapy compliance. Statistical analyses included repeated-measures ANOVA, chi-square tests, logistic regression, Kaplan-Meier survival curves, and Cox proportional hazards modeling.
resultsSignificant declines in weight, BMI, fat mass, muscle mass, and HGS occurred throughout treatment (p < 0.01), with the greatest deterioration during radiotherapy. Weight loss > 5% was associated with severe mucositis (p < 0.05), and low muscle mass was associated with longer LOHS (p < 0.05). Hypoalbuminemia (< 3.5 g/dL) predicted higher mortality (41.7% vs. 12.5%) and 30-day readmissions (50.0% vs. 13.6%). Lower albumin and reduced muscle mass showed trends toward poorer survival on Kaplan-Meier analysis; however, these differences did not reach statistical significance.
conclusionNutritional deterioration is progressive and clinically significant in oral cavity cancer and directly influences mortality and readmissions. Early identification of at-risk patients and structured, multimodal nutritional surveillance are essential. Standardized primary outcomes and robust statistical modeling strengthen clinical relevance and provide a methodological framework for designing future nutritional intervention trials.
Indexed as
Identifiers
41291316What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.