Evidence map›Paper›PMID 41291299›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Prognostic interplay between cardiac allograft vasculopathy and coronary vascular function by hybrid rubidium-82 PET/CT imaging in heart transplant population.

Roberta Assante, Emilia Zampella, Irene Mattucci, Adriana D'Antonio, Francesco Curcio, Teresa Mannarino, Pietro Buongiorno, Mariarosaria Panico, Cristiano Amarelli, Paolo Golino and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Non-invasive imaging in heart transplant recipients: state of art and future direction.European journal of nuclear medicine and molecular imaging · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Roberta AssanteDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini 5, Naples, 80131, Italy.
Emilia ZampellaDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini 5, Naples, 80131, Italy.
Irene MattucciDepartment of Cardiac Surgery and Transplants, Monaldi, A.O. dei Colli, Naples, Italy.
Adriana D'AntonioDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini 5, Naples, 80131, Italy.
Francesco CurcioDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Teresa MannarinoDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini 5, Naples, 80131, Italy.
Pietro BuongiornoDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini 5, Naples, 80131, Italy.
Mariarosaria PanicoInstitute of Biostructure and Bioimaging, National Council of Research, Naples, Italy.
Cristiano AmarelliDepartment of Cardiac Surgery and Transplants, Monaldi, A.O. dei Colli, Naples, Italy.
Paolo GolinoDepartment of Cardiac Surgery and Transplants, Monaldi, A.O. dei Colli, Naples, Italy.
Pasquale AbeteDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Francesco CacciatoreDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Alberto CuocoloDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini 5, Naples, 80131, Italy.
Wanda AcampaDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini 5, Naples, 80131, Italy. acampa@unina.it.ORCID 0000-0003-2187-4076

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe evaluated the interrelation of cardiac allograft vasculopathy (CAV) and both coronary artery calcium and coronary vascular function, as assessed rubidium-82 (

methodsA total of 100 (mean age 60 ± 13 years) consecutive patients were studied. CAC score was measured according to the Agatston method and patients were categorized into 2 groups (< 100, and ≥100). Baseline and hyperemic MBF were automatically quantified. MPR was calculated as the ratio of hyperemic to baseline MBF and it was considered reduced when < 2.

resultsDuring the mean time of 27 ± 8 months, 35 events occurred. Patients with events showed a higher prevalence of CAV, MPR impairment and CAC score > 100 as compared to patients without events. At multivariable COX analysis, CAC score, CAV and reduced MPR were independent predictors of events. In patients without previous CAV, the presence of reduced MPR was associated with higher event rate compared to normal MPR.

conclusionsIn heart transplanted patients, the presence of CAV and reduced MPR were associated with a poor prognosis and higher risk of adverse events. In patients without CAV the presence of reduced MPR was associated with worst prognosis. Thus, the early noninvasive evaluation of microcirculatory dysfunction in HT patients has important clinical implication, providing a better risk stratification and subsequent modification of treatment strategies, with a potential impact on patient management at follow-up. CLINICAL TRIAL NUMBER: not applicable.

Indexed as

Coronary Artery DiseaseCoronary VesselsHeart TransplantationPositron Emission Tomography Computed TomographyRubidium RadioisotopesAgedAllograftsFemaleHumansMaleMiddle AgedPrognosisRubidium-82Rubidium RadioisotopesCoronary artery calciumHeart transplantMyocardial blood flowMyocardial perfusion reservePET/CT

Identifiers

PMID41291299
PMCPMC12920290

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.