Observational studyJournal of cancer research and clinical oncology2025
Surgical resection for pulmonary metastases from head and neck adenoid cystic carcinoma: a propensity-matched survival analysis.
Observational study in Journal of cancer research and clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Integrated Transcriptomic Analysis ofInternational journal of molecular sciences · 2026Article
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11 authors.
Funding
Abstract
objectiveThe management of pulmonary metastases (PM) from head and neck adenoid cystic carcinoma (ACC) remains controversial, with limited evidence guiding the choice between surgical and non-surgical strategies. This study aimed to compare long-term survival outcomes between patients undergoing surgical resection and those receiving non-surgical management for ACC-derived PM.
methodsWe conducted a retrospective analysis of 204 patients with pulmonary metastases from head and neck ACC treated at our institution between January 2010 and December 2024. Patients were categorized into Surgery (n = 108) and Non-Surgery (n = 96) groups. To address selection bias and improve causal inference in this observational study, propensity score matching (PSM) was performed based on key clinical variables, generating 68 well-matched pairs. Overall survival (OS) and progression-free survival (PFS) were compared using Kaplan-Meier analysis and Cox proportional hazards models.
resultsBefore matching, the Surgery group demonstrated significantly higher 5-year OS (97.73% vs. 84.2%, P = 0.0004) and PFS (89.39% vs. 74.66%, P = 0.021). After PSM, the survival advantage persisted, with the Surgery group showing improved 5-year OS (95.75% vs. 82.91%, P = 0.0063) and PFS (86.93% vs. 73.86%, P = 0.0039). Multivariate analysis confirmed surgical resection as an independent prognostic factor for improved OS (HR = 0.08, 95% CI: 0.01-0.42, P = 0.0032), alongside tumor grade, presence of pleural effusion, and International Registry of Lung Metastases (IRLM) stage.
conclusionsIn this propensity-matched analysis, surgical metastasectomy was associated with significantly improved survival in selected patients with ACC lung metastases, supporting its consideration as a valuable therapeutic option for oligometastatic disease within a multidisciplinary framework.
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