ArticleCommunications biology2025
Formononetin derived from Parabacteroides merdae alleviates MPTP-induced Parkinson's disease in mice by inhibiting ferroptosis via the PI3K-AKT-ferritinophagy axis.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson's disease (PD) is a prevalent neurological disorder that has been increasingly linked to gut dysbiosis. However, the mechanisms by which gut microbiota regulate the pathogenesis of PD remain unclear. In this study, we model PD in male mice via MPTP-induction, and demonstrate a significant reduction in the intestinal abundance of Parabacteroides merdae (P. merdae). Administration of P. merdae to these mice alleviates MPTP-induced PD symptoms. Furthermore, P. merdae mitigates MPTP-induced PD by releasing formononetin (FMN) through β-galactosidase (β-GAL) activity. Both P. merdae and FMN administration inhibits MPTP-induced ferroptosis during PD progression. Blocking ferroptosis using ferrostatin-1 or ACSL4 knock-down also ameliorated MPTP-induced PD in mice. Mechanistically, FMN activates the PI3K-AKT pathway, which suppressed ferroptosis by restoring FTH levels via regulation of NCOA4-mediated ferritinophagy. Collectively, our findings reveal that P. merdae-derived FMN alleviates MPTP-induced PD by inhibiting ferroptosis via the PI3K-AKT-NCOA4-ferritinophagy axis, highlighting the potential therapeutic strategy for PD intervention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.