ArticlePediatric research2026
Decrease of Rho-kinase functional activity as potential complication of birth asphyxia in newborn vasculature.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBirth asphyxia is associated with neonatal acidosis in arterial blood following delivery of the baby. Acidosis during asphyxia is accompanied by the drop of blood pressure level that might be associated with the decrease of peripheral vascular resistance. However, the mechanisms of arterial relaxation in response to acidosis in the early postnatal period are scarce. We hypothesized that in early postnatal period the substantial contribution of Rho-kinase to the regulation of arterial tone is decreased under conditions of acidosis.
methodsWe modeled extracellular metabolic acidosis (pH = 6.8) and studied isolated saphenous arteries of 11-14-day-old rats by wire myography, Ca
resultsAcidosis reduced contraction and [Ca
conclusionOur data demonstrate that acidosis suppresses Rho-kinase procontractile impact in arteries in early postnatal period. IMPACT: Birth asphyxia is associated with acidosis in neonates. Acidosis during asphyxia is accompanied by the drop of blood pressure level that might be associated with the decrease of peripheral vascular resistance. Acidosis has a complex effect on the vascular tone regulation in the early postnatal period, affecting procontractile and anticontractile mechanisms in different directions. Acidosis suppresses Rho-kinase procontractile impact in arteries in early postnatal period.
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