Evidence map›Paper›PMID 41291188›Full record

ArticleMolecular psychiatry2026

MAO-B status in alcohol use disorder: a [

Laura M Best, Jennifer Truong, Tina McCluskey, Jeffrey H Meyer, Pablo Rusjan, Shahtaj S Dheda, Jerlene Pandian, Vitor S Tardelli, Dafna Sara Rubin-Kahana, Shawn G Rhind and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Laura M BestBrain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, M5T 1R8, ON, Canada.ORCID http://orcid.org/0000-0002-2197-9655
Jennifer TruongInstitute of Medical Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, M5S 3H2, ON, Canada.
Tina McCluskeyBrain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, M5T 1R8, ON, Canada.ORCID http://orcid.org/0000-0002-6795-4808
Jeffrey H MeyerBrain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, M5T 1R8, ON, Canada.ORCID http://orcid.org/0000-0003-4684-5052
Pablo RusjanBrain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, M5T 1R8, ON, Canada.ORCID http://orcid.org/0000-0003-0075-2918
Shahtaj S DhedaBrain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, M5T 1R8, ON, Canada.
Jerlene PandianBrain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, M5T 1R8, ON, Canada.
Vitor S TardelliCampbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, M6J 1H4, ON, Canada.
Dafna Sara Rubin-KahanaDepartment of Psychiatry, University of Toronto, Toronto, M5T 1R8, ON, Canada.
Shawn G RhindFaculty of Kinesiology & Physical Education, University of Toronto, Toronto, M5S 3J7, ON, Canada.
Bernard Le FollInstitute of Medical Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, M5S 3H2, ON, Canada.ORCID http://orcid.org/0000-0002-6406-4973
Jerry WarshBrain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, M5T 1R8, ON, Canada.
Stephen J KishBrain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, M5T 1R8, ON, Canada.
Isabelle BoileauBrain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, M5T 1R8, ON, Canada. isabelle.boileau@camh.ca.ORCID http://orcid.org/0000-0002-9901-1484

Funding

Investigating astrocyte status in alcohol use disorder with the novel positron emission tomography (PET) tracer [11C]SL25.1188.R21AA026680 · NIAAA · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI KISH, STEPHEN JOHN · 2019 to 2020
$283k
Fatty Acid Amide Hydrolase in treatment seeking alcohol dependent individualsR21AA022246 · NIAAA · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI BOILEAU, ISABELLE · 2014 to 2015
$278k
NIAAA NIH HHS R21 AA022246NIAAA NIH HHS R21 AA026680U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) 026680
6 · The paper itself

Abstract

Chronic alcohol exposure may trigger astrogliosis-a process involving hypertrophy and upregulation of astrocyte-specific markers following neuronal stress or injury-as suggested by trends in preclinical studies. However, in vivo evidence of astrogliosis in alcohol use disorder (AUD) is lacking. Here, we investigated the status of the astrocyte marker MAO-B -an enzyme predominantly expressed in astrocytes and upregulated during astrogliosis - using [

Indexed as

AlcoholismGliosisMonoamine OxidaseAdultAstrocytesBrainCarbon RadioisotopesFemaleGlial Fibrillary Acidic ProteinHumansMaleMiddle AgedNeurofilament ProteinsPositron-Emission TomographyCarbon RadioisotopesGlial Fibrillary Acidic ProteinMonoamine OxidaseNeurofilament Proteins

Identifiers

PMID41291188
PMCPMC12999484

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.