Evidence map›Paper›PMID 41291184›Full record

ArticleCommunications biology2025

LCRMP-1 induces tumor angiogenesis by transcriptionally upregulating SERPINE1 in lung adenocarcinoma.

Yuan-Ling Hsu, Pei-Fang Hung, Chi-Chung Wang, Yih-Leong Chang, Chen-Tu Wu, Pei-Shan Wu, Xuan-Ren Chen, Tse-Ming Hong, Pan-Chyr Yang, Szu-Hua Pan

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Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuan-Ling HsuGraduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, Taiwan.
Pei-Fang HungHeart Rhythm Center and Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Chi-Chung WangGraduate Institute of Biomedical and Pharmaceutical Science, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.ORCID http://orcid.org/0000-0002-0934-9431
Yih-Leong ChangDepartment of Pathology, National Taiwan University Cancer Center, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.ORCID http://orcid.org/0000-0001-5309-0554
Chen-Tu WuDepartment of Pathology, National Taiwan University Cancer Center, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.ORCID http://orcid.org/0000-0001-8458-4119
Pei-Shan WuChemistry Division, Center for General Education, Chang Gung University, Taoyuan, Taiwan.
Xuan-Ren ChenInstitute of Biomedical Science, Mackay Medical College, Taipei, Taiwan.
Tse-Ming HongInstitute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan.
Pan-Chyr YangDepartment of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.ORCID http://orcid.org/0000-0001-6330-6048
Szu-Hua PanGraduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, Taiwan. shpan@ntu.edu.tw.ORCID http://orcid.org/0000-0002-0138-0434

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiogenesis is a crucial process in cancer progression, particularly in malignant tumors, as it facilitates tumor growth and metastasis by generating new blood vessels that supply vital nutrients and oxygen. However, the regulatory mechanism governing the development of these tumor neo-vessels by endothelial cells is still not fully understood. This study investigates the role of long-form collapsin response mediator protein-1 (LCRMP-1) in angiogenesis within non-small cell lung cancer (NSCLC). Through in vitro tube formation, in vivo plaque angiogenesis assays, and immunohistochemical staining, we identify SERPINE1 as a crucial factor regulated by LCRMP-1. Mechanistically, LCRMP-1 functions as a co-transcriptional factor, enhancing the expression of SERPINE1 through its interactions with TP53. This enhancement promotes the secretion of SERPINE1, alters the tumor microenvironment, and assists endothelial cells in the formation of new blood vessels, thereby further advancing the progression of NSCLC.

Indexed as

Adenocarcinoma of LungCarcinoma, Non-Small-Cell LungLung NeoplasmsNeovascularization, PathologicPlasminogen Activator Inhibitor 1AngiogenesisAnimalsCell Line, TumorGene Expression Regulation, NeoplasticHumansMiceTumor MicroenvironmentTumor Suppressor Protein p53Up-RegulationPlasminogen Activator Inhibitor 1SERPINE1 protein, humanTumor Suppressor Protein p53

Identifiers

PMID41291184
PMCPMC12647825

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.