ArticleJournal of assisted reproduction and genetics2026
Reproductive outcomes of mosaic embryo transfers in preimplantation genetic testing for structural rearrangement cycles: a retrospective cohort study.
Article in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global research trends in embryonic mosaicism and mosaic embryo transfer: a bibliometric and science-mapping analysis.Frontiers in medicine · 2026Pooled it
- Mosaic embryos result in equivalent live birth rates when compared to euploid embryos following frozen embryo transfer.Journal of assisted reproduction and genetics · 2026Article
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Authors and funding
12 authors.
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Abstract
purposeTo study reproductive outcomes of transferring embryos with mosaic chromosomal aneuploidies unrelated to target loci in preimplantation genetic testing for structural rearrangement (PGT-SR).
methodsA retrospective analysis of 1712 PGT-SR cycles (involving 1373 couples) from a single center was conducted. Comprehensive chromosomal analysis was performed on trophectoderm biopsy samples using whole-genome amplification combined with next-generation sequencing. Clinical outcomes after single embryo transfer, including clinical pregnancy rate, miscarriage rate, live birth rate, and ectopic pregnancy rate, were compared between mosaic embryo transfers and completely euploid embryo transfers.
resultsIn PGT-SR cycles, euploid embryo transfers (1338 cycles) demonstrated a clinical pregnancy rate of 65.17%, live birth rate of 58.67%, miscarriage rate of 6.05%, and ectopic pregnancy rate of 0.45%, whereas mosaic embryo transfers (165 cycles) exhibited comparable outcomes with 58.18%, 54.55%, 3.64%, and 0%, respectively. The subgroup analysis by mosaic degree which revealed low-level mosaicism (20%-29% and 30%-49%) had outcomes similar to euploid embryos. High-level mosaicism (50%-69%) demonstrated significantly reduced clinical pregnancy (OR = 0.20, 95% CI 0.06-0.54) and live birth rates (OR = 0.20, 95% CI 0.06-0.56), though miscarriage remained comparable. No significant outcome variations were observed across chromosomal types.
conclusionsIn PGT-SR cycles, embryos with low-level mosaicism (20%-49%) unrelated to target loci demonstrate equivalent clinical pregnancy and live birth outcomes to completely euploid embryos. Although high-level mosaicism (50%-69%) is likely associated with reduced live birth rates, these embryos still retain potential for healthy live births.
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