Evidence map›Paper›PMID 41291132›Full record

ArticleScientific reports2025

Antitumor effects of a novel glucose-conjugated bacteriochlorin for photodynamic therapy.

Yasunari Sasaki, Mamoru Tanaka, Yuki Kojima, Makiko Sasaki, Tomohiro Watada, Ryusei Yamasaki, Kanato Matsuura, Akihiro Nomoto, Shigenobu Yano, Tomokazu Yoshimura and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yasunari SasakiDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Science, Nagoya, Aichi, Japan.
Mamoru TanakaDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Science, Nagoya, Aichi, Japan. mtanaka@med.nagoya-cu.ac.jp.ORCID 0000-0001-8416-5774
Yuki KojimaDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Science, Nagoya, Aichi, Japan.
Makiko SasakiDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Science, Nagoya, Aichi, Japan.
Tomohiro WatadaDepartment of Applied Chemistry, Graduate School of Engineering, Osaka Metropolitan University, Osaka, Japan.
Ryusei YamasakiDepartment of Applied Chemistry, Graduate School of Engineering, Osaka Metropolitan University, Osaka, Japan.
Kanato MatsuuraDepartment of Chemistry and Biology, National Institute of Technology, Fukui College, Fukui, Japan.
Akihiro NomotoDepartment of Applied Chemistry, Graduate School of Engineering, Osaka Metropolitan University, Osaka, Japan.
Shigenobu YanoKYOUSEI Science Center for Life and Nature, Nara Women's University, Nara, Japan.
Tomokazu YoshimuraDepartment of Chemistry, Faculty of Science, Nara Women's University, Nara, Japan.
Atsushi NarumiDepartment of Polymer Science and Engineering, Graduate School of Science and Engineering, Yamagata University, Yamagata, Japan.
Keiji OzekiDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Science, Nagoya, Aichi, Japan.
Takaya ShimuraDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Science, Nagoya, Aichi, Japan.
Eiji KubotaDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Science, Nagoya, Aichi, Japan.
Hiromi KataokaDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Science, Nagoya, Aichi, Japan.

Funding

Japan Society for the Promotion of Science 22K05144Japan Society for the Promotion of Science 23K07358Japan Society for the Promotion of Science 23K07421Japan Society for the Promotion of Science 23K15019Japan Society for the Promotion of Science 24K08399
6 · The paper itself

Abstract

Photodynamic therapy (PDT) is a minimally invasive cancer treatment that employs photosensitizers (PSs) activated by light to generate cytotoxic reactive oxygen species (ROS). Talaporfin sodium (TS), widely used in Japan, has shown limited efficacy in advanced tumors, highlighting the need for novel PSs. We developed a glucose-conjugated bacteriochlorin derivative, Glc-TFPB, designed to enhance tumor selectivity via the Warburg effect and to enable deep tissue penetration owing to its near-infrared absorption. In vitro, Glc-TFPB exhibited time-dependent cellular uptake, predominantly in lysosomes, and induced significant ROS generation and apoptosis upon PDT. Compared with TS, Glc-TFPB-PDT demonstrated markedly higher cytotoxicity 24 h after administration (IC50: 1.10 µM vs 13.60 µM). In vivo fluorescence analysis revealed peak tumor accumulation at 24 h after administration, consistent with optimal treatment timing. PDT with Glc-TFPB significantly suppressed tumor growth in xenografted mice, with greater efficacy at 24 h than at 2 h after administration. These findings indicate that Glc-TFPB is a promising next-generation PS with improved tumor selectivity, deeper tissue penetration, and superior photodynamic efficacy, supporting its potential for clinical translation.

Indexed as

Antineoplastic AgentsGlucoseNeoplasmsPhotochemotherapyPhotosensitizing AgentsPorphyrinsAnimalsApoptosisCell Line, TumorFemaleHumansMiceMice, Inbred BALB CMice, NudeReactive Oxygen SpeciesXenograft Model Antitumor AssaysAntineoplastic AgentsbacteriochlorinGlucosePhotosensitizing AgentsPorphyrinsReactive Oxygen SpeciesBacteriochlorinGlucose-conjugatedPhotodynamic therapyPhotosensitizerReactive oxygen speciesTalaporfin sodium

Identifiers

PMID41291132
PMCPMC12748749

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.