ArticleScientific reports2025
Age-related evolution of human gingiva towards a fibrotic-like connective phenotype.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Regenerative repair is connected to early and specific structural, immune, and metabolic MSC signatures in adult mammals.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontal disease affects most adults over 50, but the role of aging in periodontal homeostasis remains poorly understood. This study examines variations in human gingival gene expression over time using transcriptomic and histological approaches. Results show a global decline in gene expression with age, suggesting a loss of genetic information that could weaken the gingiva’s ability to respond to stressors. The findings experimentally validate the SIM (Structure, Immunity, Metabolism) paradigm, emphasizing the central role of structural components in aging. Structural changes, including reduced collagen III signaling and decreased periostin levels, indicate impaired matrix remodeling as a key feature of gingival aging. These insights mark an important step toward defining biological age at the gingival level and improving risk assessment for periodontal diseases. This research lays the foundation for predictive and preventive strategies in periodontal medicine, aiming to enhance personalized interventions and early treatments to mitigate aging-related oral health decline.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.