ReviewThe Journal of antibiotics2026
Recent advances in lincosamide biosynthetic studies.
Review in The Journal of antibiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Lincomycin A and celesticetin are representative members of the lincosamide class of clinically used antibiotics produced by Streptomyces species. Their distinctive chemical architectures arise from atypical biosynthetic gene clusters that lack well observed signature genes, and since the complete determination of the lincomycin A biosynthetic pathway, current research has focused on the genetic manipulation of regulatory elements and the protein engineering of biosynthetic enzymes. This review summarizes recent advances in elucidating the transcriptional regulation of lincosamide biosynthetic gene clusters and the structure-function relationships and engineering of their biosynthetic enzymes.
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