Evidence map›Paper›PMID 41291020›Full record

ArticleScientific reports2025

Pathogen-focused metagenomic analysis reveals predominance of human rotavirus genotypes G3 and G12 in Zambian pediatric diarrhea cases.

Innocent Mwape, Suwilanji Silwamba, Kennedy Chibesa, Charlie C Luchen, Kalo Musukuma-Chifulo, John Collins, Adriace Chauwa, Fraser Liswaniso, Tamara B Nzangwa, Dhvani H Kuntawala and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Innocent Mwape *Faculty of Health Sciences, Stellenbosch University, Cape town, South Africa.
Suwilanji Silwamba *Research Department, Basic Science and Immunology, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Kennedy ChibesaResearch Department, Basic Science and Immunology, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Charlie C LuchenResearch Department, Basic Science and Immunology, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Kalo Musukuma-ChifuloResearch Department, Basic Science and Immunology, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
John CollinsDepartment of Population and Family Health, Mailman School of Public Health, Columbia University, New York, 10032, USA.
Adriace ChauwaResearch Department, Basic Science and Immunology, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Fraser LiswanisoResearch Department, Basic Science and Immunology, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Tamara B NzangwaResearch Department, Basic Science and Immunology, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Dhvani H KuntawalaResearch Department, Basic Science and Immunology, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Caroline C ChisengaResearch Department, Basic Science and Immunology, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Corena De BeerFaculty of Health Sciences, Stellenbosch University, Cape town, South Africa.
Roma ChilengiResearch Department, Basic Science and Immunology, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
X J LuGlobal Alliance for Preventing Pandemics, Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, 10032, USA.
Sam YingstGlobal Alliance for Preventing Pandemics, Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, 10032, USA.
J Kenneth WickiserGlobal Alliance for Preventing Pandemics, Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, 10032, USA.
Michelo SimuyandiResearch Department, Basic Science and Immunology, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia. Michelo.Simuyandi@cidrz.org.

Funding

DELTAS Africa DEL-22-012
6 · The paper itself

Abstract

Despite global improvements in water, sanitation, and rotavirus vaccination, rotavirus-associated diarrhea continues to cause significant morbidity and mortality among children in low-to-middle-income countries. Genomic surveillance is essential for evaluating vaccine efficacy and detecting emerging escape variants. In this study, we used VirCapSeq-VERT (VCS) to analyze rotavirus genetic diversity during Zambia's 2023 diarrhea surveillance. Stool samples from under five children with diarrhea were collected from health facilities across nine provinces. Out of 245 samples, 72 were rotavirus qPCR-positive with C

Indexed as

DiarrheaMetagenomicsRotavirusRotavirus InfectionsChild, PreschoolFecesFemaleGenetic VariationGenome, ViralGenotypeHumansInfantMalePhylogenyZambiaDiarrheaGenomic surveillanceRotavirusSequencingVirCapSeq-VERT

Identifiers

PMID41291020
PMCPMC12748673

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.