ArticleScientific reports2025
Association of the non-HDL cholesterol to HDL cholesterol ratio with possible sarcopenic obesity in Chinese adults.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Sarcopenic obesity (SO) is a major public health concern linked to lipid metabolism disorders. This study investigated the association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and possible SO prevalence in China using data from the 2015 China Health and Retirement Longitudinal Study (CHARLS). Among 3,320 participants(21.02% men; median age 66.00 years [interquartile range, IQR 62.00-71.00]), multivariate logistic regression revealed that individuals in the highest NHHR tertile had a 66% increased risk of possible SO compared to the lowest tertile. Restricted cubic spline analysis identified a significant nonlinear relationship (p < 0.05). A two-piecewise regression model showed that for NHHR < 3.262, the adjusted odds ratio (OR) for possible SO was 2.27 (95% CI, 1.48-3.45; p < 0.001), whereas for NHHR ≥ 3.262, the OR was 0.97 (95% CI, 0.78-1.21; p = 0.78). This finding suggests that NHHR could serve as a novel and convenient biomarker for possible SO risk stratification; maintaining an NHHR below 3.262 may be a valuable target for preventing possible SO in the middle-aged and elderly Chinese population.
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