Evidence map›Paper›PMID 41290918›Full record

ArticleScientific reports2025

Exploring the effect and mechanism of baicalin on sepsis-induced acute lung injury based on network pharmacology and experimental verification.

Pengwei Wang, Ru Zhang, Miaomiao Liu, Jianlian Gao, Yongheng Zhang, Xiaohong Liu, Caixia Li, Yuanyuan Zhao, Tiantian Zhu, Xinghua Zhao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pengwei WangDepartment of Clinical Pharmacy, The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui, 453100, Henan, China.
Ru ZhangDepartment of Clinical Pharmacy, The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui, 453100, Henan, China.
Miaomiao LiuDepartment of Clinical Pharmacy, The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui, 453100, Henan, China.
Jianlian GaoDepartment of Clinical Pharmacy, The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui, 453100, Henan, China.
Yongheng ZhangDepartment of Clinical Pharmacy, The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui, 453100, Henan, China.
Xiaohong LiuDepartment of Clinical Pharmacy, The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui, 453100, Henan, China.
Caixia LiDepartment of Clinical Pharmacy, The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui, 453100, Henan, China.
Yuanyuan ZhaoDepartment of Clinical Pharmacy, The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui, 453100, Henan, China.
Tiantian ZhuCollege of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China. zhutt@xxmu.edu.cn.
Xinghua ZhaoBasic Medical College, Xinxiang Medical University, Xinxiang, 453003, Henan, China. zphx1985@163.com.
Zhijian DengDepartment of Clinical Pharmacy, The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui, 453100, Henan, China. deng710402@163.com.

Funding

Medical Science and Technology Research Project of Henan Province LHGJ20240476
6 · The paper itself

Abstract

Baicalin (BA) is an active component of the natural plant Scutellaria baicalensis, which has been used over many years to treat inflammation and respiratory infections. In this study, the sepsis-induced acute lung injury (ALI) mouse model, network pharmacology and molecular docking were used to predict and explore the potential targets and signaling pathways of BA against ALI. The results showed that BA inhibited the major characteristics of ALI, including pathological changes, alveolar-capillary barrier dysfunction, increased inflammatory response and M1 macrophage polarization. Based on network pharmacology and molecular docking analyses, the PI3K/AKT/NF-κB pathway might be an important mechanism by which BA mitigated sepsis-induced ALI. Moreover, BA attenuated the phosphorylation of PI3K, AKT, IκB and NF-κB in the lung tissues of the ALI mice. In conclusion, this study demonstrated that BA ameliorated lung injury in mice, and depressed M1 macrophage polarization through inhibition of the PI3K/AKT/NF-κB pathway.

Indexed as

Acute Lung InjuryFlavonoidsSepsisAnimalsBronchoalveolar LavageBronchoalveolar Lavage FluidCapillariesDisease Models, AnimalMacrophagesMaleMiceMice, Inbred C57BLMolecular Docking SimulationNetwork PharmacologyNF-kappa BPhosphatidylinositol 3-KinasesbaicalinFlavonoidsNF-kappa BPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAcute lung injuryBaicalinMacrophage polarizationMolecular dockingNetwork pharmacologySepsis

Identifiers

PMID41290918
PMCPMC12647782

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.