Evidence map›Paper›PMID 41290917›Full record

ArticleScientific reports2025

Outbreaks of post-weaning diarrhea caused by ETEC F4 are strongly associated with CHCF1 genotype in Danish pigs.

Martin Peter Rydal, Kimmie Kyed Lyderik, Amanda Bastian Andersen, Claus Bøttcher Jørgensen, Peter Damborg, Jens Peter Nielsen

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Martin Peter RydalDepartment of Veterinary and Animal Sciences, University of Copenhagen, Animal Welfare and Disease Control, Frederiksberg, Denmark. martin.rydal@sund.ku.dk.
Kimmie Kyed LyderikDepartment of Veterinary and Animal Sciences, University of Copenhagen, Animal Welfare and Disease Control, Frederiksberg, Denmark.
Amanda Bastian AndersenDepartment of Veterinary and Animal Sciences, University of Copenhagen, Animal Welfare and Disease Control, Frederiksberg, Denmark.
Claus Bøttcher JørgensenDepartment of Veterinary and Animal Sciences, University of Copenhagen, Animal Welfare and Disease Control, Frederiksberg, Denmark.
Peter DamborgDepartment of Veterinary and Animal Sciences, Section for Bacteria and Viruses, University of Copenhagen, Frederiksberg, Denmark.
Jens Peter NielsenDepartment of Veterinary and Animal Sciences, University of Copenhagen, Animal Welfare and Disease Control, Frederiksberg, Denmark.

Funding

Innovationsfonden File number: 7076-00038BNovo Nordisk Fonden NNFSA210073688
6 · The paper itself

Abstract

Enterotoxigenic Escherichia coli (ETEC) of fimbriae types F4 and F18 causes post-weaning diarrhea (PWD) in pigs and susceptibility relates to host genotype. We examined if CHCF1/FUT1 genotypes were associated with ETEC-mediated PWD in seven Danish herds. Diarrhea was assessed in 1,919 pigs by evaluating perianal fecal staining in the first week after weaning. From each herd, twelve diarrheic and twelve non-diarrheic pigs were selected for genotyping, fecal dry matter (FDM) and microbiological testing. ETEC F4 diarrhea occurred only in CHCF1 heterozygous (RS) pigs. Furthermore, CHCF1 RS pigs had higher odds of diarrhea (Odds ratio (OR) 2.09; p = 0.026) and lower mean FDM (13.9%) than homozygous resistant (RR) pigs (18.6%; p = 0.0052). ETEC F4 was more frequently isolated from CHCF1 RS pigs compared to RR pigs (OR 8.88, p = 0.00005). Additionally, hemolytic E. coli shedding was higher in CHCF1 RS pigs (mean 47.4% vs. 24.1%; p = 0.00001). Too few FUT1 RR pigs were found for analyzing association between FUT1 genotypes and ETEC F18-mediated diarrhea. In conclusion, CHCF1 genotype was strongly associated with ETEC F4-mediated PWD under production settings. ETEC F4 resistance in pigs could help to reduce PWD occurrence and antibiotic use.

Indexed as

DiarrheaDisease OutbreaksEnterotoxigenic Escherichia coliEscherichia coli InfectionsEscherichia coli ProteinsFimbriae ProteinsSwine DiseasesAnimalsDenmarkFecesFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseGenotypeSwineWeaningEscherichia coli ProteinsFimbriae ProteinsFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseCHCF1Enterotoxigenic Escherichia coliF18 fimbriaeF4 fimbriaeFUT1Post-weaning diarrhea

Identifiers

PMID41290917
PMCPMC12647900

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.