ArticleScientific reports2025
Modulation of experimental Alzheimer's disease in rats through donepezil-loaded CSF implant.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Modulating Cerebrospinal Fluid Composition in Neurodegenerative Processes: Modern Drug Delivery and Clearance Strategies.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is a growing challenge worldwide, with current treatments largely symptomatic and limited. The current study aimed to introduce coated nanoporous membranes for localized drug delivery of donepezil, combining both antifouling activity and sustained drug release, unlike traditional Alzheimer's treatments that rely on systemic administration. Nanoporous membranes were prepared by electrochemical anodization, coated with Polymethyl methacrylate (PMMA) or a PMMA/polyurethane (PU) mixture to mitigate biofouling. The fabricated nanoporous membranes before and after coating were characterized using SEM/EDX, FTIR, BET, and contact angle measurements. In vitro drug release and release kinetics were studied in artificial cerebrospinal fluid (ACSF). Coated and donepezil loaded membranes were implanted on the dura surface in Wistar rats AD model via intracerebral streptozotocin (STZ) injection. The activity was evaluated on behavioral, biochemical and histological levels. PMMA enhanced membrane hydrophobicity (contact angle increased from 62.8° to 79°) and sustained drug release over 7 days, making it the preferred coating. The PMMA membrane demonstrated a reduction in beta-amyloid levels without being loaded with donepezil, while the donepezil-loaded membrane showed cognitive function improvement in Morris water maze and Y-maze. Acetylcholinesterase activity was elevated after STZ-induction of AD and got ameliorated by the membranes implantation. Brain-Derived Neurotrophic Factor (BDNF) was lowered by STZ, while increased in treated animals. Histological examination revealed the neuronal regeneration after donepezil-loaded PMMA coated membrane. These findings suggest that coated nanoporous membranes are promising systems for localized active donepezil drug delivery for AD-like symptoms modulation in STZ-induced AD model, warranting further validation in other AD paradigms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.