ArticleScientific reports2025
A novel sulfonamide derivative suppresses gastrointestinal cancer progression by targeting Axin2 and β-catenin.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Gastrointestinal cancer is a major global health risk with rising incidence and limited effective therapeutic options. Despite advancements in diagnostics and therapies, the aggressive nature of these malignancies make novel therapeutic strategies essential. This study synthesized and evaluated a novel sulfonamide derivative, compound 2406, for its antiproliferative effects in gastrointestinal cancer cell lines (EC-9706, SGC-7901, and HT-29). Molecular docking and biological assays were conducted to assess its potential binding and interaction with β-tubulin and the Wnt/β-catenin signaling pathway, with a focus on EC-9706 and HT-29 cell lines. Compound 2406 significantly inhibited tumor cell invasion, migration, and colony formation. It induced G2/M phase cell cycle arrest in EC-9706 and HT-29 cells, reducing cellular proliferation. Molecular docking and in vitro experiments confirmed that compound 2406 interfered with β-tubulin cytoskeletal integrity and suppressed Wnt/β-catenin signaling, which is critical for tumor progression. These findings highlight the therapeutic potential of compound 2406 as a novel anticancer agent targeting β-tubulin and Wnt/β-catenin signaling in gastrointestinal cancer. Further in vivo studies would be warranted to validate its efficacy and clinical applicability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.