Evidence map›Paper›PMID 41290879›Full record

ArticleScientific reports2025

Electric fields unlock a transient vulnerability window for vancomycin-based treatment of staphylococcal biofilms.

M Balato, E Roscetto, C Petrarca, M Vitelli, M Aversa, U Galdiero, M R Catania, L Costanzo, S M Soto, M Mariconda and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

M BalatoDepartment of Electrical Engineering and Information Technologies (DIETI), University of Naples Federico II, Via Claudio 21, Napoli (NA), 80125, Italy. marco.balato@unina.it.
E RoscettoDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via Pansini 5, Napoli (NA), 80131, Italy. emanuela.roscetto@unina.it.
C PetrarcaDepartment of Electrical Engineering and Information Technologies (DIETI), University of Naples Federico II, Via Claudio 21, Napoli (NA), 80125, Italy.
M VitelliDepartment of Engineering, Università degli Studi della Campania "Luigi Vanvitelli", Via Roma, Aversa (CE), 81031, Italy.
M AversaDepartment of Public Health, University of Naples Federico II, Via Pansini 5, Napoli, 80131, NA, Italy.
U GaldieroDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via Pansini 5, Napoli (NA), 80131, Italy.
M R CataniaDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via Pansini 5, Napoli (NA), 80131, Italy.
L CostanzoDepartment of Engineering, Università degli Studi della Campania "Luigi Vanvitelli", Via Roma, Aversa (CE), 81031, Italy.
S M SotoISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
M MaricondaDepartment of Public Health, University of Naples Federico II, Via Pansini 5, Napoli, 80131, NA, Italy.
G BalatoDepartment of Public Health, University of Naples Federico II, Via Pansini 5, Napoli, 80131, NA, Italy.

Funding

European Union-Next Generation EU in the framework of PRIN 2022 under grant 2022Z8C472, project title: Advanced Management of PEriprosthetic joint infections based on biofilm electrical featuREs - AMPERE. 2022Z8C472
6 · The paper itself

Abstract

Bacterial biofilms pose a significant challenge to antibiotic treatment. Conventional therapeutic interventions often fail to effectively eradicate mature biofilms due to the protective extracellular matrix and altered physiological states of the embedded bacteria. In this study, we show that low-intensity sinusoidal electric fields induce a time-limited window of vulnerability in mature Staphylococcus aureus biofilms, increasing their susceptibility to vancomycin. In particular, the simultaneous application of electric fields and vancomycin during a transient vulnerability window results in a potentiated effect, leading to an approximately 3-log

Indexed as

Anti-Bacterial AgentsBiofilmsElectricityStaphylococcus aureusVancomycinMicrobial Sensitivity TestsStaphylococcal InfectionsAnti-Bacterial AgentsVancomycin

Identifiers

PMID41290879
PMCPMC12647763

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.