Evidence map›Paper›PMID 41290734›Full record

ArticleNature communications2025

Evidence for divergent cortical organisation in Parkinson's disease and Lewy Body Dementia.

Angeliki Zarkali, George Thomas, Naomi Hannaway, Ivelina Dobreva, Melissa Grant Peters, Martina F Callaghan, Mina Ryten, Rimona S Weil

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Angeliki ZarkaliDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK. a.zarkali@ucl.ac.uk.ORCID http://orcid.org/0000-0003-2808-072X
George ThomasDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID http://orcid.org/0000-0001-6107-0326
Naomi HannawayDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID http://orcid.org/0000-0001-8608-7757
Ivelina DobrevaDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID http://orcid.org/0000-0002-9401-1899
Melissa Grant PetersDementia Research Institute, University of Cambridge, Cambridge, UK.
Martina F CallaghanDepartment of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID http://orcid.org/0000-0003-0374-1659
Mina RytenDementia Research Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-9520-6957
Rimona S WeilDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID http://orcid.org/0000-0002-5092-6325

Funding

Alzheimer's Research UK (ARUK) 2018B-001Wellcome TrustWellcome Trust (Wellcome) 205263/Z/22/Z
6 · The paper itself

Abstract

Dementia is a defining feature of Lewy body disease: its timing and onset distinguish different clinical diagnoses, and its effect on quality of life is profound. However, it remains unclear whether processes leading to cognitive and motor symptoms in Lewy body disease differ. To clarify this, we use in-vivo neuroimaging to assess spatial gradients of inter-regional differences in structural and functional connectivity in 108 people across the Lewy body disease spectrum (46 Parkinson's with normal cognition (PD-NC), 62 Lewy body dementia (LBD)) and 23 controls. We show divergent structural gradient differences with cognitive impairment: PD-NC show increased inter-regional differentiation, whilst LBD show overall gradient distribution similar to controls despite widespread organisational differences at the regional level. We then assess cellular and molecular underpinnings of these organisational changes. We reveal similarities and also important differences in the drivers of cortical organisation between LBD and PD-NC, particularly in layer 4 excitatory neurons.

Indexed as

Cerebral CortexLewy Body DiseaseParkinson DiseaseAgedAged, 80 and overCase-Control StudiesCognitive DysfunctionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimaging

Identifiers

PMID41290734
PMCPMC12749319

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.