Glutamate, NAA, and energy metabolism in clinical high risk and first episode psychosis.

Bridget King, Matthew J Kempton, Shue Kit Man, Alice Egerton, Romina Mizrahi

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bridget KingDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Matthew J KemptonDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Shue Kit ManDouglas Research Centre, Clinical and Translational Sciences Lab, Montreal, QC, Canada.

Alice EgertonDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. alice.egerton@kcl.ac.uk.

Romina MizrahiDouglas Research Centre, Clinical and Translational Sciences Lab, Montreal, QC, Canada.

Funding

CIHR APP400704Medical Research Council MR/N013700/1

6 · The paper itself

Abstract

Regulation of brain glutamate is closely related to brain energy metabolism. Changes in both central glutamatergic function and peripheral energy metabolism have been implicated in psychosis risk, onset and long-term illness, but there is a lack of empirical evidence to link these processes. We investigated the relationships between glutamate and N-acetyl-aspartate (NAA, a potential marker of neuronal metabolic integrity) in the anterior cingulate cortex (ACC), measured using proton magnetic resonance spectroscopy (

Indexed as

Aspartic AcidEnergy MetabolismGlutamic AcidPsychotic DisordersAdolescentAdultFemaleGyrus CinguliHumansMaleMitochondriaProton Magnetic Resonance SpectroscopyYoung AdultAspartic AcidGlutamic AcidN-acetylaspartateClinical high riskEnergy metabolismFirst episode psychosisGlutamateMitochondrial functionNAA

Identifiers

PMID41290713

DOI10.1038/s41598-025-22845-y

PMCPMC12658253

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.