ArticleNature communications2025
Topological turning points across the human lifespan.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Article
- Heterochronicity shapes brain network formation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Progressive Hippocampal Volume Reduction Beyond Normal Aging in Temporal Lobe Epilepsy: A Longitudinal MRI Study.Epilepsia open · 2026Article
- Balancing harm prevention and liberty preservation when implementing financial risk assessments for gambling in the United Kingdom: Insights from open banking data.Addiction (Abingdon, England) · 2026Article
- Charting confidence in white matter brain charts: enabling study planning through stability validation.Journal of medical imaging (Bellingham, Wash.) · 2026Article
- The past and future of neuropsychological assessment: Back to the origins to face digital technological changes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- Brain network-based stratification of mental health disorders: design and cohort description of the STRATIFY and ESTRA studies.Molecular psychiatry · 2026Review
- Multiscale brain development across the human lifespan.Communications biology · 2026Review
- Biological aging clocks in health and disease.Nature medicine · 2026Review
- Functional Expression of Nicotinic Receptors on iPSC-Derived Astrocytes and Signalling Disturbances by a Panel of Neonicotinoid Pesticides and Their Metabolites.International journal of molecular sciences · 2026Article
- The Amygdala and Politics.Brain sciences · 2026Review
- Nourish the mind: protocol for an umbrella review on nutrients and bioactive food components supporting brain health across the lifespan.Systematic reviews · 2026Article
- Next-Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS.Cell proliferation · 2026Review
- Breaking down the ADHD construct to build a valid diagnosis.Acta neuropsychiatrica · 2026Review
- Developing a multi-modal neuroimaging-based BrainAge model across childhood.bioRxiv : the preprint server for biology · 2026Article
- Continual learning of multiple cognitive functions with a brain-inspired temporal development mechanism.National science review · 2026Article
- Brain Age in Adult Patients With Early-Treated Phenylketonuria.Journal of inherited metabolic disease · 2026Article
- Exploring the ALS Multistep Model.Brain sciences · 2026Review
- Assessing the Roles of Aging, Estrogen, Nutrition, and Neuroinflammation in Women and Their Involvement in Alzheimer's Disease-A Narrative Overview.International journal of molecular sciences · 2026Review
- Receptive prosody adaptation to contextual feedback in autistic young adults.Frontiers in psychology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Structural topology develops non-linearly across the lifespan and is strongly related to cognitive trajectories. We gathered diffusion imaging from datasets with a collective age range of zero to 90 years old (N = 4,216). We analyzed how 12 graph theory metrics of organization change with age and projected these data into manifold spaces using Uniform Manifold Projection and Approximation. With these manifolds, we identified four major topological turning points across the lifespan - around nine, 32, 66, and 83 years old. These ages defined five major epochs of topological development, each with distinctive age-related changes in topology. These lifespan epochs each have a distinct direction of topological development and specific changes in the organizational properties driving the age-topology relationship. This study underscores the complex, non-linear nature of human development, with unique phases of topological maturation, which can only be illuminated with a multivariate, lifespan, population-level perspective.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.