ArticleNature communications2025
Magnetic and pneumatic actuation of polymeric microneedles for plasmonic hot-spot engineering and molecular sensing.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Bioelectronic Considerations in Biomedical Microneedles.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Soft actuators offer dynamic control of plasmonic particle gaps for hot-spot engineering, yet their potential remains underexplored. Here, we demonstrate two polymeric microneedle platforms designed for precise hot-spot generation and molecular sensing. The first employs magnetic actuation, embedding Fe particles into microneedles to enable reversible deformation under magnetic fields, with stable performance over 1000 cycles. Decorating these structures with silver nanoparticles yields strong surface-enhanced Raman scattering amplification. The second utilizes pneumatic actuation with polydimethylsiloxane microneedles, providing greater flexibility and tip contact area under negative pressure. When functionalized with gold nanoparticles, the microneedles achieve ~3.0-fold higher Raman signals than magnetic counterparts. To demonstrate multifunctionality, we integrate independent vacuum sources and a robotic arm for cargo transport and selective molecular detection. These dynamic microneedle platforms overcome limitations of conventional approaches and offer programmable, tunable, and scalable solutions for plasmon-enhanced sensing in diverse real-world applications.
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Registered trials
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