Evidence map›Paper›PMID 41290647›Full record

ArticleNature communications2025

Impact of a community-based antiretroviral therapy delivery model for people living with HIV in Cambodia.

Ziya Tian, Pheak Chhoun, Sovannary Tuot, Lo Yan Esabelle Yam, Michiko Nagashima-Hayashi, Marina Zahari, Sok Chamreun Choub, Sovannarith Sameth, Bora Ngauv, Vichea Ouk and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ziya TianSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.ORCID http://orcid.org/0009-0001-5606-8552
Pheak ChhounKHANA Centre for Population Health Research, Phnom Penh, Cambodia.
Sovannary TuotKHANA Centre for Population Health Research, Phnom Penh, Cambodia.ORCID http://orcid.org/0000-0001-8617-4578
Lo Yan Esabelle YamSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Michiko Nagashima-HayashiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Marina ZahariSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.ORCID http://orcid.org/0000-0002-1451-6628
Sok Chamreun ChoubKHANA Centre for Population Health Research, Phnom Penh, Cambodia.
Sovannarith SamethNational Centre for HIV/AIDS, Dermatology, and STD, Phnom Penh, Cambodia.
Bora NgauvNational Centre for HIV/AIDS, Dermatology, and STD, Phnom Penh, Cambodia.
Vichea OukNational Centre for HIV/AIDS, Dermatology, and STD, Phnom Penh, Cambodia.
Alvin Kuo Jing TeoSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.ORCID http://orcid.org/0000-0002-0569-3518
Kiesha PremSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Siyan YiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore. siyan@nus.edu.sg.ORCID http://orcid.org/0000-0002-3045-5386

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cambodia achieved the UNAIDS 90-90-90 targets in 2017; however, clinic congestion, stigma, and mental health disparities continue to challenge sustained HIV care. This quasi-experimental study evaluated a community-based antiretroviral therapy delivery model compared with multi-month dispensing among people living with HIV across 20 clinics (N = 4,089) from 2021 to 2023. Baseline and endline surveys and clinical data assessed treatment adherence, viral suppression, retention in care, stigma, depressive symptoms, and quality of life. Both approaches achieved high retention in care (>97%) and viral suppression rates (>99%). The community-based model showed significantly improved adherence, reduced depressive symptoms, and higher physical health-related quality of life. Modest reductions in experienced stigma were observed, but effects on internalised and anticipated stigma were inconclusive. These findings indicate that community-based antiretroviral therapy delivery effectively sustains adherence and improves health outcomes, supporting its integration into Cambodia's HIV care system alongside interventions targeting stigma reduction.

Indexed as

Anti-HIV AgentsAnti-Retroviral AgentsHIV InfectionsAdultCambodiaDepressionFemaleHumansMaleMedication AdherenceMiddle AgedQuality of LifeSocial StigmaViral LoadAnti-HIV AgentsAnti-Retroviral Agents

Identifiers

PMID41290647
PMCPMC12749388

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.