ArticleNature communications2025
mop1 affects maize recombination landscapes by modulating methylation of MITEs near genes in open chromatin.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Wild tomato genome assemblies reveal structural variants and repeat content act as recombination barriers.Nature communications · 2026Article
- The epigenetic landscape of heterosis: integrating multi-layer regulatory insights and navigating the path to causality.Frontiers in plant science · 2026Review
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Authors and funding
5 authors.
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Abstract
Meiotic recombination generates new genetic combinations and ensures proper chromosome segregation, yet its regulation remains unclear in many species. Here, we show that Mediator of paramutation1 (Mop1), a regulator of DNA methylation, affects the recombination landscape in maize. High-resolution crossover mapping reveals that loss of MOP1 reduces crossover numbers during male meiosis, while the total number in female meiosis remains largely unchanged despite local shifts in crossover distribution. We find that new crossovers occur on miniature inverted-repeat transposable elements (MITEs), particularly in regions with greater genetic diversity. Analysis of DNA methylation and histone modifications, together with gene expression, shows that loss of MOP1 reduces methylation at MITEs near genes enriched with histone marks linked to open and active chromatin, and downregulates a gene required for chromosome organization. Together, these findings suggest that both chromosome structure and transposon methylation contribute to recombination control, providing insights into epigenetic control of genetic variation.
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