ArticleNature communications2025
Tetrazine-enhanced donor-acceptor-donor metal-organic frameworks for photodynamic antibacterial therapy and wound healing.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Oxygen-vacancy-rich LDH sonosensitizers potentiate narrow-spectrum antibiotics via membrane-disruption strategy for mixed bacterial wound infections.Bioactive materials · 2027Article
- NIR-Assisted Multimodal Strategies for Enhanced Antibacterial Therapy.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Ultrasound-programmable adhesive hydrogel platform for sequential treatment of infected wounds.Materials today. Bio · 2026Article
- Protonated Defect-Engineered Carbon Nitride Enables Bio-Interface-Enhanced Photodynamic Antibacterial Activity with Potential Periodontal Application.Materials (Basel, Switzerland) · 2026Article
- A ROS-responsive core-shell microneedle platform integrating sonodynamic gas antibacterial therapy and modulating immunity for diabetic wound healing.Journal of nanobiotechnology · 2026Article
- Multifunctional Toona sinensis gum polysaccharide-based carbon dot-hydrogel composites for accelerated healing of infected wounds.Journal of nanobiotechnology · 2026Article
- Dual-metallic porphyrinic MOFs with pH/ROS-responsive release for antibacterial and antioxidant therapy of diabetic infected wounds.Theranostics · 2026Article
- Type I Framework Complex: Photocontrolled Superoxide Anion Generator.Research (Washington, D.C.) · 2026Review
- Advanced applications of cationic photosensitizer DHPC in photodynamic eradication of drug-resistant bacteria.Frontiers in microbiology · 2026Article
- Coordination-based nanocomposite hydrogel promotes tissue regeneration under infection-compromised conditions.Regenerative biomaterials · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
Abstract
Multidrug-resistant infections and impaired healing in chronic diabetic wounds are major clinical challenges. Photodynamic therapy (PDT) is a promising alternative, but its efficacy is limited by conventional photosensitizers. Here, we design two donor-acceptor-donor (D-A-D) metal-organic frameworks (MOFs) using a tetrazine core to narrow the band gap, which enhances visible-light-driven reactive oxygen species (ROS) generation. These MOFs exhibit superior photocatalytic antibacterial activity over benchmark materials. After functionalization with L-arginine, the resulting composites (e.g., A@Zn-TDP) co-release ROS, nitric oxide (NO), and reactive nitrogen species (RNS) enabling rapid and broad-spectrum bacterial eradication (including against MRSA) at low concentrations (25 μg/mL) while accelerating tissue regeneration. In a male diabetic mouse model, A@Zn-TDP treatment under light reduces bacterial load by >95%, controls inflammation, promotes angiogenesis, and speeds up wound closure. This study establishes tetrazine-based D-A-D MOFs as a rationally designed platform for effective PDT and wound healing, underscoring their clinical translational potential.
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