ArticleSignal transduction and targeted therapy2025
Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury.
Abstract read
In one paragraph
Article in Signal transduction and targeted therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of thymosin α1 combined with chemotherapy for gastric cancer: a systematic review and meta-analysis of randomized controlled trials.Frontiers in immunology · 2026Pooled it
- The gut microbiota as a regulator of intestinal stem-cell fate: bacterial and fungal control of differentiation and regeneration.Gut microbes · 2026Review
- The role of the gut microbiota in radiation enteritis: from mechanistic insights to therapeutic applications.Communications biology · 2026Review
- Intestinal stem cells as innate immune sentinels: coupling environmental sensing to epithelial adaptation.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
43 authors.
Julius C Fischer *Department of Radiation Oncology, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany. julius.fischer@tum.de.ORCID 0000-0002-6951-3416
Sascha Göttert *Department for Internal Medicine III, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.
Maximilian GillerDepartment of Radiation Oncology, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.
Paul HeinrichUniversity Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany.ORCID 0000-0002-6149-2083
Kaiji FanUniversity Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany.
Omer KhalidUniversity Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany.
Caroline N WaltherDepartment of Radiation Oncology, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.
Maria DrießleinUniversity Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany.
Sophie M NefzgerDepartment of Radiation Oncology, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.
Gabriel EisenkolbDepartment for Internal Medicine III, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.ORCID 0000-0002-0717-5861
Vincent R TimnikDepartment of Radiation Oncology, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.
Sebastian JaroschTechnical University of Munich (TUM), TUM School of Medicine and Health, Institute for Medical Microbiology, Immunology and Hygiene, Munich, Germany.ORCID 0000-0002-2908-8590
Lena KlostermeierDepartment for Internal Medicine III, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.
Thomas EngleitnerTechnical University of Munich, TUM School of Medicine and Health, Center for Translational Cancer Research (TranslaTUM), Munich, Germany.
Nicholas StriederLeibniz Institute for Immunotherapy (LIT), Regensburg, Germany.ORCID 0000-0003-1183-1099
Claudia GebhardLeibniz Institute for Immunotherapy (LIT), Regensburg, Germany.
Sarah DiederichDepartment of Radiation Oncology, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.
Nicole A SchmidDepartment of Radiation Oncology, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.ORCID 0009-0002-7461-7321
Laura Lansink RotgerinkDepartment of Radiation Oncology, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.
Laura JoachimDepartment for Internal Medicine III, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.
Sakhila GhimireUniversity Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany.
Eva VonbrunnDepartment of Nephropathology, Institute of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.ORCID 0000-0003-0418-0267
Maike Büttner-HeroldDepartment of Nephropathology, Institute of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.ORCID 0000-0002-9974-6683
Marianne RemkeTechnical University of Munich (TUM), TUM School of Medicine and Health, Comparative Experimental Pathology, Munich, Germany.
Katja SteigerTechnical University of Munich (TUM), TUM School of Medicine and Health, Comparative Experimental Pathology, Munich, Germany.ORCID 0000-0002-7269-5433
Rupert ÖllingerTechnical University of Munich, TUM School of Medicine and Health, Center for Translational Cancer Research (TranslaTUM), Munich, Germany.
Roland RadTechnical University of Munich, TUM School of Medicine and Health, Center for Translational Cancer Research (TranslaTUM), Munich, Germany.
Daniel WolffUniversity Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany.
Markus FeuererLeibniz Institute for Immunotherapy (LIT), Regensburg, Germany.
Petra HoffmannUniversity Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany.ORCID 0009-0003-3541-6196
Matthias EdingerUniversity Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany.ORCID 0000-0003-2889-2533
Michael RehliUniversity Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany.
Markus TschurtschenthalerTechnical University of Munich, TUM School of Medicine and Health, Center for Translational Cancer Research (TranslaTUM), Munich, Germany.ORCID 0000-0002-0060-4790
Oliver KeppCentre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.ORCID 0000-0002-6081-9558
Guido KroemerCentre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.ORCID 0000-0002-9334-4405
Erik Thiele OrbergDepartment for Internal Medicine III, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.
Stephanie E CombsDepartment of Radiation Oncology, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.
Wolfgang HerrUniversity Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany.
Florian BassermannDepartment for Internal Medicine III, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.
Dirk H BuschTechnical University of Munich (TUM), TUM School of Medicine and Health, Institute for Medical Microbiology, Immunology and Hygiene, Munich, Germany.ORCID 0000-0001-8713-093X
Ernst HollerUniversity Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany.
Simon HeideggerDepartment for Internal Medicine III, Technical University of Munich (TUM), TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.ORCID 0000-0001-6394-5130
Hendrik PoeckUniversity Hospital Regensburg, Department for Internal Medicine III, Hematology & Oncology, Regensburg, Germany. hendrik.poeck@ukr.de.
Funding
Deutsche Forschungsgemeinschaft (German Research Foundation) 324392634Deutsche Forschungsgemeinschaft (German Research Foundation) 360372040Deutsche Forschungsgemeinschaft (German Research Foundation) 395357507Deutsche Forschungsgemeinschaft (German Research Foundation) 509149993Deutsche Forschungsgemeinschaft (German Research Foundation) BA 2851/6-1Deutsche Forschungsgemeinschaft (German Research Foundation) PO 1575/5-1Deutsche Forschungsgemeinschaft (German Research Foundation) Projektnummer 324392634Deutsche Krebshilfe (German Cancer Aid) 70113964Deutsche Krebshilfe (German Cancer Aid) 70114547EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 101124680Else Kröner-Fresenius-Stiftung (Else Kroner-Fresenius Foundation) 2019_A149Else Kröner-Fresenius-Stiftung (Else Kroner-Fresenius Foundation) 2022_EKMS.26Wilhelm Sander-Stiftung (Wilhelm Sander Foundation) 2021.041.1Wilhelm Sander-Stiftung (Wilhelm Sander Foundation) 2023.072.1
Abstract
Intestinal stem cells (ISCs) promote tissue repair after genotoxic or immune-mediated injury. However, ISCs are particularly sensitive to various stressors and primary targets of overwhelming immune responses, such as interferon γ (IFNγ)-mediated killing. In mouse models of radiation therapy-induced gut damage and in biopsies from patients who underwent allogeneic hematopoietic stem cell transplantation, we observed IFNγ expression by intestinal T
Indexed as
InflammationInterferon-gammaInterleukin-10Intestinal MucosaIntestinesT-Lymphocytes, RegulatoryAnimalsHematopoietic Stem Cell TransplantationHumansMiceOrganoidsStem CellsIL10 protein, humanInterferon-gammaInterleukin-10
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.