Evidence map›Paper›PMID 41290375›Full record

ArticleMedical physics2025

Adaptation of a small animal radiation research platform for pre-clinical microbeam irradiations.

Lauren Yeomans, Kimia Gharehkhani, Craig Cummings, Joanna Wilk, Carol Box, Simeon Nill, Uwe Oelfke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lauren YeomansDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK and Joint Department of Physics, The Royal Marsden NHS Foundation Trust, London, UK.
Kimia GharehkhaniDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK and Joint Department of Physics, The Royal Marsden NHS Foundation Trust, London, UK.
Craig CummingsDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK and Joint Department of Physics, The Royal Marsden NHS Foundation Trust, London, UK.
Joanna WilkDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK and Joint Department of Physics, The Royal Marsden NHS Foundation Trust, London, UK.
Carol BoxDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK and Joint Department of Physics, The Royal Marsden NHS Foundation Trust, London, UK.
Simeon NillDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK and Joint Department of Physics, The Royal Marsden NHS Foundation Trust, London, UK.
Uwe OelfkeDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK and Joint Department of Physics, The Royal Marsden NHS Foundation Trust, London, UK.

Funding

Cancer Research UK Multidisciplinary Award
6 · The paper itself

Abstract

backgroundMicrobeam radiotherapy (MRT) was introduced as a method to widen the therapeutic window compared to standard radiotherapy treatments. Studies have shown the normal tissue sparing effects of MRT, whilst maintaining the tumor control of standard broad beam radiotherapy. PURPOSE: To create and test a microbeam (MB) delivery system compatible with a small animal radiation research platform (SARRP, Xstrahl), which would allow the machine to be easily adapted to deliver MB irradiations without making any permanent changes to the system.

methodsA MB collimator was designed, that fits in with the existing SARRP infrastructure and can easily be removed to revert the machine back to a normal broad beam delivery system. A translatable mousebed was developed to reduce the source-to-surface distance (SSD) for MB delivery, allowing the target position to be moved between imaging and treatment. Gafchromic film was used to test the accuracy of the positioning, and to determine the dose rates achievable in a solid water phantom.

resultsAt 1 mm depth in solid water, a peak-to-valley dose ratio (PVDR) of 46 was achieved when the target was placed directly under the collimator, whilst a PVDR of 29 was reached when a 10.5 mm air gap was introduced between the collimator and target. Integral dose rates at 1 mm depth for these setups were 0.93 ± 0.04 and 0.94 ± 0.01 Gy/min, respectively. Conversion between broad beam and microbeam setup was found to take less than 5 min.

conclusionsOur adaptations enable any SARRP machine to be converted into a MB delivery system, with feasibility studies confirming MB delivery in a solid water phantom. The system is now routinely used to deliver MBs for in vivo studies.

Indexed as

RadiotherapyAnimalsMicePhantoms, ImagingRadiotherapy Dosagemicrobeamradiotherapyspatial fractionation

Identifiers

PMID41290375
PMCPMC12646974

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