Evidence map›Paper›PMID 41290005›Full record

ArticleCurrent biology : CB2025

Asymmetric lateral habenula function and peripheral neural mechanisms in regulating itch-evoked scratching.

Suna L Cranfill, Huasheng Yu, Yingqi Wang, Juan M Inclan-Rico, Emma Janke, Karina Lezgiyeva, Shibo Liu, Annabel Chang, Steven Gooden, Jane Baker and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Suna L CranfillDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Huasheng YuDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yingqi WangDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Juan M Inclan-RicoDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Emma JankeDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Karina LezgiyevaDepartment of Neurobiology, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Shibo LiuDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Annabel ChangDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Steven GoodenDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jane BakerDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sepenta ShirvanDepartment of Neuroscience, Howard Hughes Medical Institute, Scripps Research, La Jolla, CA 92037, USA.
Qinxue WuDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Janardhan P BhattaraiDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Rose Z HillDepartment of Neuroscience, Howard Hughes Medical Institute, Scripps Research, La Jolla, CA 92037, USA; Department of Chemical Physiology and Biochemistry, Vollum Institute, and Division of Nephrology and Hypertension, Oregon Health & Science University, Portland, OR 97239, USA.
Minghong MaDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: minghong@pennmedicine.upenn.edu.
Wenqin LuoDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: luow@pennmedicine.upenn.edu.

Funding

The Penn Human Precision Pain Center (HPPC): Discovery and Functional Evaluation of Human Primary Somatosensory Neuron Types at Normal and Chronic Pain ConditionsU19NS135528 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Mingyao Li, Wenqin Luo · 2023 to 2026
$11.2M
Olfactory Modulation of Respiration-Entrained Brain Activity and BehaviorR01DC006213 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI MA, MINGHONG · 2005 to 2024
$8.2M
Underpinnings of corneal innervation: anatomical, molecular, and functional studies of corneal sensory afferents in physiologic and pathologic statesU01EY034681 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Vivian Lee, Wenqin Luo · 2022 to 2026
$5.5M
Molecular mechanisms in controlling development of touch-sensing neuronsR01NS083702 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI LUO, WENQIN · 2013 to 2022
$4.1M
Determine Functions of the Lateral Habenular and Trigeminal High Threshold Mechanoreceptors in Mediating Scratching-induced ResponsesR01NS131209 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Wenqin Luo · 2023 to 2026
$2.1M
Functional interrogation of sensory neurons in inflammationR00NS133478 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Rose Z Hill · 2025 to 2026
$495k
Functional interrogation of sensory neurons in inflammationK99NS133478 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI HILL, ROSE Z · 2023 to 2024
$240k
Contributions of itch-sensing neurons to skin anti-helminth immunityK99AI187730 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI INCLAN RICO, JUAN MANUEL · 2025 to 2025
$185k
The role of the lateral habenula in central pain and itch processingF31DE029361 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI LI, SUNA · 2019 to 2022
$115k
NEI NIH HHS U01 EY034681NIAID NIH HHS K99 AI187730NIDCD NIH HHS R01 DC006213NIDCR NIH HHS F31 DE029361NINDS NIH HHS K99 NS133478NINDS NIH HHS R00 NS133478NINDS NIH HHS R01 NS083702NINDS NIH HHS R01 NS131209NINDS NIH HHS U19 NS135528
6 · The paper itself

Abstract

Itch is an aversive sensory experience inextricably linked to a desire to scratch.

Indexed as

HabenulaPruritusAnimalsChloroquineFemaleMaleMiceChloroquineasymmetric brain functionchemogeneticsitchLHbNP1 afferentoptogeneticsPiezo2scratchTRAP labeling

Identifiers

PMID41290005
PMCPMC12662393

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.