ArticleImmunity2025
Topography of the HLA-A protein enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients.
Abstract read
In one paragraph
Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Not all Mismatches Were Created Equal: Empirical Identification of Regions Within HLA-DQ Molecules That Harbor the Highest Immunogenicity.Transplantation · 2026Article
- Profiling Allogeneic HLA-specific B-cell Responses Utilizing a 64-plex Single-HLA Reporter Cell Panel.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
- Update of
Authors and funding
27 authors.
John T KillianDepartment of Surgery, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
R Glenn KingDepartment of Microbiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Aaron C K LucanderDepartment of Microbiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
James L KizziahDepartment of Microbiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Christopher F FucileDepartment of Informatics and Data Science, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Ruben Diaz-AvalosCenter for Infectious Disease and Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Shihong QiuDepartment of Microbiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Aaron Silva-SanchezDepartment of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Betty J MousseauDepartment of Microbiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Kevin J MaconDepartment of Microbiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Amanda R CallahanDepartment of Microbiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Guang YangDepartment of Microbiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
M Emon HossainDepartment of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Jobaida AktherDepartment of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Daryl B GoodNicoya, Kitchener, ON, Canada.
Susan KelsoNicoya, Kitchener, ON, Canada.
Julie A HoupDepartment of Surgery, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Frida RosenblumDepartment of Pathology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Paige M PorrettDepartment of Surgery, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Song C OngDepartment of Medicine, Division of Nephrology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Vineeta KumarDepartment of Medicine, Division of Nephrology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Erica Ollmann SaphireCenter for Infectious Disease and Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
John F KearneyDepartment of Microbiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Troy D RandallDepartment of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Alexander F RosenbergDepartment of Microbiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA; Department of Informatics and Data Science, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Todd J GreenDepartment of Microbiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA. Electronic address: tgreen@uab.edu.
Frances E LundDepartment of Microbiology, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA. Electronic address: flund@uab.edu.
Funding
XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9MVirology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1MTissue and organ specific human B cell immunity: Supplement - Metabolic Risk Factors and Inflammation in PASC DevelopmentU19AI142737 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TECTOR, A JOSEPH · 2019 to 2023
$19.7MProject 3: Evolution, dynamics and durability of B cell and antibody responses in lung transplantationU19AI181105 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Troy D Randall · 2024 to 2026
$13.9MIMMUNOLOGIC DISEASES AND BASIC IMMUNOLOGYT32AI007051 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Laurie Ellen Harrington · 1985 to 2026
$13.1McGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1MTRAINING IN CELLULAR PHYSIOLOGY MEMBRANE TRANSPORTT32DK007545 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M · 1987 to 2023
$4.5MAcquisition of cryo-electron microscopeS10OD024978 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DOKLAND, TERJE · 2020 to 2020
$2.0MAcquisition of a High Precision Micro Diffractometer to Support NIH funded Research at SER-CATS10OD027000 · OD · UNIVERSITY OF GEORGIA · PI ROSE, JOHN PATRICK · 2019 to 2019
$600kAcquition of a microdiffractometer for SER-CATS10RR025528 · NCRR · UNIVERSITY OF GEORGIA · PI ROSE, JOHN PATRICK · 2009 to 2009
$414kNCI NIH HHS P30 CA013148NCRR NIH HHS S10 RR025528NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIAID NIH HHS P30 AI027767NIAID NIH HHS T32 AI007051NIAID NIH HHS U19 AI142737NIAID NIH HHS U19 AI181105NIDA NIH HHS 75N95020D00005NIDDK NIH HHS T32 DK007545NIH HHS S10 OD024978NIH HHS S10 OD027000ORFDO NIH HHS 75N99020D00005
Abstract
Donor-specific antibody responses against human leukocyte antigen (HLA) proteins mismatched between transplant donors and recipients cause allograft loss, yet the structural HLA epitopes targeted by alloreactive B cells and antibodies remain largely unresolved. We profiled the HLA-A
Indexed as
B-LymphocytesGraft RejectionHLA-A AntigensImmunodominant EpitopesIsoantibodiesKidney TransplantationEpitopes, B-LymphocyteHumansTransplant RecipientsEpitopes, B-LymphocyteHLA-A AntigensImmunodominant EpitopesIsoantibodiesalloimmunityantibodiesB lymphocytesimmunodominancekidneymemory B cellsprotein epitopestopographytransplantation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.