Evidence map›Paper›PMID 41289992›Full record

ArticleCell stem cell2025

Space-associated stem cell hallmarks of aging and resilience in astronauts.

Jessica Pham, Shuvro P Nandi, Larisa Balaian, Claire Engstrom, Patrick Chang, Karla Mack, Inge van der Werf, Emma Klacking, Jenna Sneifer, Neha Katragadda and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Jessica PhamSanford Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Shuvro P NandiDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Larisa BalaianSanford Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Claire EngstromSanford Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Patrick ChangSanford Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Karla MackSanford Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Inge van der WerfSanford Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Emma KlackingSanford Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Jenna SneiferSanford Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Neha KatragaddaSanford Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Kendale WirtjesSanford Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Antonio RuizSanford Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Daisy Chilin-FuentesCenter for Computational Biology and Bioinformatics, University of California, San Diego, La Jolla, CA, USA.
Elsa MolinaNext Generation Sequencing Core, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Pinar MesciAxiom Space, Houston, TX, USA.
Jana StoudemireSanford Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Sheldon R MorrisSanford Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Thomas WhisenantCenter for Computational Biology and Bioinformatics, University of California, San Diego, La Jolla, CA, USA.
Ludmil B AlexandrovSanford Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Catriona H M JamiesonSanford Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA. Electronic address: cjamieson@health.ucsd.edu.

Funding

San Diego Nathan Shock CenterP30AG068635 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SHADEL, GERALD · 2020 to 2024
$6.0M
Characterization of the Role of ADAR1 in Oncogenic Transformation of ProgenitorsR01CA205944 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAMIESON, CATRIONA HELEN MACLEOD · 2017 to 2021
$1.8M
Defining the Niche-dependent Role of RNA Editing in Aged and MDS Hematopoietic Stem and Progenitor Cell DysfunctionR01DK114468 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAMIESON, CATRIONA HELEN MACLEOD · 2017 to 2021
$1.7M
Exploring the Impact of Base Deaminase Deregulation on Precancer EvolutionR01CA296974 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Catriona Helen Macleod Jamieson · 2025 to 2026
$890k
NCI NIH HHS R01 CA205944NCI NIH HHS R01 CA296974NIA NIH HHS P30 AG068635NIDDK NIH HHS R01 DK114468
6 · The paper itself

Abstract

Previous reports revealed immune dysfunction, chromosomal abnormalities, cytokine deregulation, and telomere alterations after prolonged spaceflight. However, the stress of space on hematopoietic stem and progenitor cells (HSPCs) and the resilience properties maintaining lifelong hematopoiesis and immunity were not studied. We performed HSPC functionally organized multi-omics aging and resilience (HSPC-FOMA-R) analyses in 9 astronauts before, during, and after three short-duration International Space Station (ISS) missions. Whole-genome sequencing (with telomere length analysis and mitochondrial and clonal mutational profiling), whole-transcriptome sequencing (with RNA editing and retrotransposon analyses), single-cell RNA sequencing, cytokine arrays, and fluorescence-activated cell sorting (FACS) analyses assessed HSPC and immune subpopulation survival dynamics. We show that spaceflight is associated with partially reversible changes in HSPC survival and self-renewal, adenosine deaminase associated with RNA1 (ADAR1), telomere maintenance, mobilization, cell cycle, and "fight or flight" gene expression. Combined with clonal hematopoietic mutations, apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC3C) activation, and retrotransposon deregulation, HSPC-FOMA-R analyses are needed before extended missions.

Indexed as

AgingAstronautsHematopoietic Stem CellsSpace FlightAdultCellular SenescenceHumansMaleMiddle AgedADAR1APOBEC3Castronautsclonal mutationshematopoietic stem and progenitor cellsmitochondriaresilienceretrotransposonsspaceflighttelomere

Identifiers

PMID41289992
PMCPMC12826796

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.