ArticleJournal of autoimmunity2026
Prior murine neurotropic coronavirus infection ameliorates experimental autoimmune encephalitis.
Article in Journal of autoimmunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCentral nervous system (CNS) infections contribute to the development of neuroinflammation and neurodegenerative diseases. However, the mechanisms underlying the correlation between CNS infection and subsequent inflammatory course remain largely unknown.
methodsHere, we addressed this question by infecting mice with a sublethal dose of a well-studied neurotropic coronavirus, mouse hepatitis virus (MHV), and investigated the effects of infection on the subsequent induction of a mouse multiple sclerosis (MS) model (myelin oligodendrocyte glycoprotein 35-55 (MOG
resultsUnexpectedly, C57BL/6J mice that recovered from MHV infection showed alleviated clinical signs of induced EAE. Mechanistically, this protection is mediated by a novel CNS-resident Foxp3
conclusionThis study reveals a novel post-infectious anti-inflammatory milieu that develops in MHV-infected CNS of MHV and leads to the generation of Foxp3
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