Evidence map›Paper›PMID 41289658›Full record

ArticleBioorganic & medicinal chemistry2026

Polynitrogen-containing compounds as multi-target sEH/FAAH inhibitors: Structure-activity relationship and pharmacological studies.

Amanda Tsang, Cassandra Yuan, Manuel Berumen, Leah Duong, Karen Gomez, Shelby Seely, Alex Salgado, Adim Rai, Jo Vistosa, Edith Morales Munoz and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Amanda TsangDepartment of Chemistry & Biochemistry, California State University, Fullerton, 800 N. State College, Fullerton, CA 92834, United States.
Cassandra YuanDepartment of Chemistry & Biochemistry, California State University, Fullerton, 800 N. State College, Fullerton, CA 92834, United States.
Manuel BerumenDepartment of Chemistry & Biochemistry, California State University, Fullerton, 800 N. State College, Fullerton, CA 92834, United States.
Leah DuongDepartment of Chemistry & Biochemistry, California State University, Fullerton, 800 N. State College, Fullerton, CA 92834, United States.
Karen GomezDepartment of Chemistry & Biochemistry, California State University, Fullerton, 800 N. State College, Fullerton, CA 92834, United States.
Shelby SeelyDepartment of Chemistry & Biochemistry, California State University, Fullerton, 800 N. State College, Fullerton, CA 92834, United States.
Alex SalgadoDepartment of Chemistry & Biochemistry, California State University, Fullerton, 800 N. State College, Fullerton, CA 92834, United States.
Adim RaiDepartment of Psychology, California State University, East Bay, 25800 Carlos Bee Blvd. Science S229, Hayward, CA 94542, United States.
Jo VistosaDepartment of Psychology, California State University, East Bay, 25800 Carlos Bee Blvd. Science S229, Hayward, CA 94542, United States.
Edith Morales MunozDepartment of Psychology, California State University, East Bay, 25800 Carlos Bee Blvd. Science S229, Hayward, CA 94542, United States.
Marcos E OrtegaWoody L. Hunt School of Dental Medicine, Texas Tech University Health Sciences Center, El Paso, 130 Rick Francis St., El Paso, TX 79905, United States.
Christophe MorisseauDepartment of Entomology and Nematology, and UCD Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, United States.
Bruce D HammockDepartment of Entomology and Nematology, and UCD Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, United States.
Jake E ZuckermanSchool of Materials Engineering and School of Mechanical Engineering, Purdue University, 585 Purdue Mall, West Lafayette, IN 47907, United States.
Joseph YountSchool of Materials Engineering and School of Mechanical Engineering, Purdue University, 585 Purdue Mall, West Lafayette, IN 47907, United States.
Davin G PierceySchool of Materials Engineering and School of Mechanical Engineering, Purdue University, 585 Purdue Mall, West Lafayette, IN 47907, United States.
Ram KandasamyDepartment of Psychology, California State University, East Bay, 25800 Carlos Bee Blvd. Science S229, Hayward, CA 94542, United States. Electronic address: ram.kandasamy@csueastbay.edu.
Stevan PecicDepartment of Chemistry & Biochemistry, California State University, Fullerton, 800 N. State College, Fullerton, CA 92834, United States. Electronic address: specic@fullerton.edu.

Funding

UC Davis CounterACT Center of Excellence: Developing Therapeutic Strategies for Mitigating the Chronic Neurological Consequences of Acute Organophosphate IntoxicationU54NS127758 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HEIKE WULFF · 2022 to 2026
$17.2M
Supplement for bioactive lipids as effectors and indicators of the deleterious effects of human healthR35ES030443 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MORISSEAU, CHRISTOPHE HP · 2019 to 2025
$5.8M
Designed Multiple Ligands as Non-opioid Analgesics for Treating Chronic PainR16GM149204 · NIGMS · CALIFORNIA STATE UNIVERSITY FULLERTON · PI Stevan Pecic · 2023 to 2026
$650k
NIEHS NIH HHS R35 ES030443NIGMS NIH HHS R16 GM149204NINDS NIH HHS U54 NS127758
6 · The paper itself

Abstract

Both soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH) are involved in degradation of anti-inflammatory and antinociceptive lipids, thus inhibition of these enzymatic pathways represents a novel strategy in the discovery of non-opioid drugs for treating inflammatory pain. We previously discovered several multi-targeted designed ligands and described a pharmacophore necessary for inhibition of both sEH and FAAH. The potential for optimization on the left side of the pharmacophore led us to exploration of different heterocyclic moieties with the hope to keep strong inhibition potencies, but to increase the metabolic stability and solubility of new analogs. Eighteen analogs containing various substituted and unsubstituted pyrimidinyl-, quinoxalinyl- and tetrazolyl- rings are synthesized and tested for inhibition potency in human FAAH, and human, rat and mouse sEH. The structure-activity relationship study revealed quinoxalinyl- analog 4 m, the most potent dual inhibitor reported to date, with IC

Indexed as

AmidohydrolasesEnzyme InhibitorsEpoxide HydrolasesNitrogenAnimalsDose-Response Relationship, DrugFatty Acid Amide HydrolasesHumansMaleMiceMicrosomes, LiverMolecular StructureRatsStructure-Activity RelationshipAmidohydrolasesEnzyme InhibitorsEpoxide HydrolasesFatty Acid Amide HydrolasesNitrogenEnzyme inhibitionHigh‑nitrogen drugsMicrosome liver assayMicrowave-assisted synthesisMulti-target directed ligandsStructure-activity relationshipWheel running

Identifiers

PMID41289658
PMCPMC12814486

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.