SynthesisInvestigacion y educacion en enfermeria2025
Evidence-Based Pathways to Healthy Aging: A Systematic Review and Meta-analysis of Lifestyle Interventions for Longevity and Well-Being.
Synthesis in Investigacion y educacion en enfermeria, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate the impact of multidimensional lifestyle interventions on aging outcomes, including cognitive function, physical health, emotional well-being, and longevity. Methods: This systematic review included 35 randomized controlled trials from 2014 through 2024 using MeSH terms such as "healthy aging," "nutrition," "physical activity," "mental health," "social connections," and "preventive healthcare." Inclusion was made based on whether studies have explored at least one lifestyle intervention among populations of 50 years and above with a reported outcome related to health and aging. Results: 35 RCTs (n ≈ 25 000 participants) were included. Key findings were: Nutrition: The Mediterranean diet, antioxidant-rich foods, and protein intake were associated with cardiovascular benefits (RR = 0.78), reduced cognitive decline (OR = 0.72), and improved muscle mass (SMD = 0.45). Physical Exercise: Aerobic and resistance exercises enhanced cardiovascular fitness (MD in VO2 max = 3.6 mL/kg/min) as well as risk of frailty (RR = 0.67); Mental Health: Cognitive stimulation and mindfulness interventions reduced the risk of dementia (OR = 0.75) as well as stress levels (Standard Mean Difference -SMD = -0.65); Network Social: Friendship support interventions with community involvement attenuated the susceptibility to depression, by 30% (RR = 0.70), with improved life overall satisfaction (SMD = 0.55); Safe Harm Avoidance: Smoking treatment reduced cardiovascular outcome risks (OR = 0.68), though moderate alcoholism was associated with better liver overall function (SMD = -0.38); Sleep: Insomnia was related to a 25% reduced risk of cognitive decline when kept at 7-8 hours (RR = 0.75), and Cognitive Behavioral Therapy for Insomnia was highly effective in enhancing quality of sleep (SMD = 0.74); Preventive Healthcare: Routine checkup reduced the un-diagnosed chronic conditions by 40% (RR = 0.60) and the vaccination programs reduced the influenza-related hospital admissions (OR = 0.58). Conclusion: Lifestyle interventions are significant in promoting life expectancy, cognitive performance, and overall well-being. The most comprehensive benefits of delay of age-related decline will be offered by the integration of multiple lifestyle factors, including balanced diets, regular exercise, cognitive engagement, strong social ties, and preventive healthcare.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.