Evidence map›Paper›PMID 41289399›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Lamprey

Ryo Morimoto, Gaoqun Zhang, Oliver S Thomas, Margaret F Docker, Jonah L Yick, Floriaan Devloo-Delva, Jeremy Swann, Dagmar Diekhoff, Thomas Boehm

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ryo MorimotoMax Planck Institute of Immunobiology and Epigenetics, Freiburg D-79108, Germany.ORCID 0000-0002-5497-4666
Gaoqun ZhangMax Planck Institute of Immunobiology and Epigenetics, Freiburg D-79108, Germany.ORCID 0009-0003-5788-2454
Oliver S ThomasMax Planck Institute of Immunobiology and Epigenetics, Freiburg D-79108, Germany.
Margaret F DockerDepartment of Biological Sciences, University of Manitoba, Winnipeg, MB RT3 2N2, Canada.
Jonah L YickInland Fisheries Service, New Norfolk, TAS 7140, Australia.ORCID 0000-0001-5464-0458
Floriaan Devloo-DelvaAustralian National Fish Collection, National Collections and Marine Infrastructure, Commonwealth Scientific and Industrial Research Organization, Hobart, TAS 7000, Australia.ORCID 0000-0002-6757-2949
Jeremy SwannMax Planck Institute of Immunobiology and Epigenetics, Freiburg D-79108, Germany.
Dagmar DiekhoffMax Planck Institute of Immunobiology and Epigenetics, Freiburg D-79108, Germany.
Thomas BoehmMax Planck Institute of Immunobiology and Epigenetics, Freiburg D-79108, Germany.ORCID 0000-0001-5172-7478

Funding

Deutsche Forschungsgemeinschaft (DFG) Project 256073931-SFB 1160EC | ERC | HORIZON EUROPE European Research Council (ERC) 834302Max Planck Gesellschaft N/A
6 · The paper itself

Abstract

All vertebrate adaptive immune systems exhibit distinct lymphocyte lineages. In jawless vertebrates, such as lampreys, T-like cells are thought to develop in lympho-epithelial structures at the tips of gill filaments, termed thymoids. However, it is unclear whether thymoids are functionally equivalent to the thymus of jawed vertebrates. Indeed, because the structural modules that are somatically assembled to form the antigen receptors of jawless and jawed vertebrates differ, development and selection of T cells may be governed by clade-specific genetic networks. To address this question, we have replaced the mouse

Indexed as

Epithelial CellsFish ProteinsForkhead Transcription FactorsLampreysThymus GlandAnimalsB-LymphocytesCell DifferentiationMiceMice, TransgenicT-LymphocytesFish ProteinsForkhead Transcription FactorsWhn proteinFoxn1lampreylymphocytesmousethymus

Identifiers

PMID41289399
PMCPMC12685072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.