Evidence map›Paper›PMID 41289390›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Actin isoform-specific interactions revealed by

Elena Kudryashova, Mark A B Kreutzberger, Ewa Niedzialkowska, Songyu Dong, Dmitri S Kudryashov, Edward H Egelman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elena Kudryashova *Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.
Mark A B Kreutzberger *Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22903.
Ewa NiedzialkowskaDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22903.
Songyu DongDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.
Dmitri S KudryashovDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.ORCID 0000-0003-1782-3305
Edward H EgelmanDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22903.ORCID 0000-0003-4844-5212

Funding

Cryo-EM of Helical Protein and Nucleoprotein Polymers at Near Atomic ResolutionR35GM122510 · NIGMS · UNIVERSITY OF VIRGINIA · PI EDWARD H. EGELMAN · 2017 to 2026
$7.3M
Name Molecular mechanisms of bacterial toxins targeting actin cytoskeletonR01GM114666 · NIGMS · OHIO STATE UNIVERSITY · PI KUDRYASHOV, DMITRI · 2015 to 2025
$3.8M
300 keV Liquid Helium Robotic MicroscopeS10RR025067 · NCRR · UNIVERSITY OF VIRGINIA · PI EGELMAN, EDWARD H. · 2009 to 2009
$2.0M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM114666HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM122510NCRR NIH HHS S10 RR025067NIGMS NIH HHS R01 GM114666NIGMS NIH HHS R35 GM122510
6 · The paper itself

Abstract

Despite an evolutionary separation of over 300 Mya, there are no amino acid substitutions in certain actin isoforms from reptiles to mammals. What divergence that does exist between different actin isoforms is primarily tissue-specific, rather than species-specific. Sorting of actin isoforms into distinct cellular compartments is believed to be controlled by actin-binding proteins (ABPs), but little is known about how ABPs can differentiate between actin isoforms. We show that the actin-binding repeat (ABR) of the

Indexed as

ActinsBacterial ProteinsVibrio parahaemolyticusAnimalsCryoelectron MicroscopyHumansProtein BindingProtein IsoformsActinsBacterial ProteinsProtein Isoformsbacterial pathogenesiscryo-EMeukaryotic evolution

Identifiers

PMID41289390
PMCPMC12685140

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.